Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis

Figure 1

The experimental protocol. OVA sensitization was followed by OVA challenge to trigger AR development. Briefly, on days 0, 7, and 14, mice in the OVA and BPA groups were sensitized with 2 mg of aluminum hydroxide (100 μL of solution) and OVA (100 μg) via intraperitoneal injection; control mice received PBS alone. Mice in the BPA group were subcutaneously injected with 0.5 mg/kg/day BPA in corn oil on days 0–14; the other two groups received only corn oil. The OVA and BPA groups were intranasally challenged with 100 μg OVA in 20 μL PBS on days 21–27. The control group received PBS alone. OVA: ovalbumin; AR: allergic rhinitis; BPA: bisphenol A; PBS: phosphate-buffered saline.