Research Article

Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population

Table 2

Association of clinical characteristics with genotype and allele frequencies in NCF2, NCF4, and CYBA genes among different groups ( (%)).

SNPAlleleClinical featuresGroupGenotypes (%) valueAlleles (%) value
(M/m)MMMmmmMm

All
rs10911363T/GAnti-CCPPositive128 (26.28)255 (52.36)104 (21.35)0.110511 (52.46)463 (47.54)0.206
Negative28 (37.33)31 (41.33)16 (21.33)87 (58.00)63 (42.00)
RFPositive126 (26.30)256 (53.44)97 (20.25)0.122508 (53.03)450 (46.97)0.806
Negative30 (30.93)41 (42.27)26 (26.80)101 (52.06)93 (47.94)
rs3794624G/AAnti-CCPPositive346 (71.05)132 (27.10)9 (1.85)0.172824 (84.60)150 (13.40)0.416
Negative52 (69.33)19 (25.33)4 (5.33)123 (82.00)27 (18.00)
RFPositive340 (70.98)128 (26.72)11 (2.30)0.682808 (84.34)150 (15.66)0.946
Negative68 (70.10)28 (28.87)1 (1.03)164 (84.54)30 (15.46)
rs4673G/AAnti-CCPPositive421 (86.45)66 (13.55)00.238908 (93.22)66 (6.78)0.257
Negative61 (81.33)14 (28.67)0136 (90.67)14 (9.33)
RFPositive409 (85.39)69 (14.41)1 (0.21)0.904887 (92.59)71 (7.41)0.925
Negative83 (85.57)14 (14.43)0180 (92.78)14 (7.22)
rs1883112A/GAnti-CCPPositive241 (49.49)201 (41.27)45 (9.24)0.880683 (70.12)291 (29.88)0.976
Negative36 (48.00)33 (44.00)6 (8.00)105 (70.00)45 (30.00)
RFPositive238 (49.69)192 (40.08)49 (10.23)0.076668 (69.73)290 (30.27)0.697
Negative45 (46.39)48 (49.48)4 (4.12)138 (71.13)56 (28.87)
rs4821544T/CAnti-CCPPositive384 (78.85)99 (20.33)4 (0.82)0.598867 (89.01)107 (10.99)0.392
Negative62 (82.67)13 (17.33)0137 (91.33)13 (8.67)
RFPositive378 (78.91)97 (20.25)4 (0.84)0.609853 (89.04)105 (10.96)0.489
Negative79 (81.44)18 (18.56)0176 (90.72)18 (9.28)
rs729749C/TAnti-CCPPositive188 (38.60)215 (44.15)84 (17.25)0.820591 (60.68)383 (39.32)0.754
Negative29 (38.67)31 (41.33)15 (20.00)89 (59.33)61 (40.67)
RFPositive183 (38.20)215 (44.89)81 (16.91)0.676581 (60.65)377 (39.35)0.533
Negative36 (37.11)41 (42.27)20 (20.62)113 (58.25)81 (41.75)
Female
rs10911363T/GAnti-CCPPositive86 (21.18)218 (53.69)102 (25.12)0.162390 (48.03)422 (51.97)0.265
Negative13 (21.31)26 (42.62)22 (36.07)52 (42.62)70 (57.38)
RFPositive98 (24.69)220 (55.42)79 (19.9)0.074416 (52.39)378 (47.61)0.680
Negative24 (29.63)34 (41.98)23 (28.40)82 (50.62)80 (49.38)
rs3794624G/AAnti-CCPPositive283 (69.70)115 (28.33)8 (1.97)0.360681 (83.87)131 (16.13)0.597
Negative42 (68.85)16 (26.23)3 (4.92)100 (81.97)22 (18.03)
RFPositive277 (69.77)110 (27.71)10 (2.52)0.750664 (83.63)130 (16.37)0.919
Negative56 (69.14)24 (29.63)1 (1.23)136 (83.95)26 (16.05)
rs4673G/AAnti-CCPPositive352 (86.70)54 (13.30)00.096109 (89.34)13 (10.66)0.110
Negative48 (78.69)13 (21.31)0758 (93.35)54 (6.65)
RFPositive341 (85.89)55 (13.85)1 (0.25)0.660737 (92.82)57 (7.18)0.517
Negative67 (82.72)14 (17.28)0148 (91.36)14 (8.64)
rs1883112A/GAnti-CCPPositive202 (49.75)171 (42.12)33 (8.13)0.844575 (70.81)237 (29.19)0.658
Negative28 (45.90)28 (45.90)5 (8.20)84 (68.85)38 (31.15)
RFPositive201 (50.63)162 (40.81)34 (8.56)0.151564 (71.03)230 (28.97)0.629
Negative35 (43.21)42 (51.85)4 (4.94)112 (69.14)50 (30.86)
rs4821544T/CAnti-CCPPositive324 (79.80)78 (19.21)4 (0.99)0.694726 (89.41)86 (10.59)0.983
Negative48 (78.69)13 (21.31)0109 (89.34)13 (10.66)
RFPositive317 (79.85)76 (19.14)4 (1.01)0.625710 (89.42)84 (10.58)0.974
Negative64 (79.01)17 (20.99)0145 (89.51)17 (10.49)
rs729749C/TAnti-CCPPositive150 (36.95)187 (46.06)69 (17.00)0.978487 (59.98)325 (40.02)0.840
Negative22 (36.07)28 (45.90)11 (18.03)72 (59.02)50 (40.98)
RFPositive148 (37.28)184 (46.35)65 (16.37)0.513480 (60.45)314 (39.55)0.247
Negative26 (32.10)38 (46.91)17 (20.99)90 (55.56)72 (44.44)
Male
rs10911363T/GAnti-CCPPositive26 (32.10)37 (45.68)18 (22.22)0.71189 (54.94)73 (45.06)0.570
Negative6 (42.86)5 (35.71)3 (21.43)17 (60.71)11 (39.29)
RFPositive28 (34.15)36 (43.90)18 (21.95)0.94892 (56.10)72 (43.90)0.732
Negative6 (37.50)7 (43.75)3 (18.75)19 (59.38)13 (40.63)
rs3794624G/AAnti-CCPPositive63 (77.78)17 (20.99)1 (1.23)0.360143 (88.27)19 (11.73)0.367
Negative10 (71.43)3 (21.43)1 (7.14)23 (82.14)5 (17.86)
RFPositive63 (76.83)18 (21.95)1 (1.22)0.880144 (87.80)20 (12.20)0.962
Negative12 (75.00)4 (25.00)028 (87.50)4 (12.50)
rs4673G/AAnti-CCPPositive69 (85.19)12 (14.81)00.441150 (92.59)12 (7.41)0.458
Negative13 (92.86)1 (7.14)027 (96.43)1 (3.57)
RFPositive68 (82.93)14 (17.07)00.074150 (91.46)14 (8.54)0.086
Negative16 (100.00)0032 (100.00)0
rs1883112A/GAnti-CCPPositive39 (48.15)30 (37.04)12 (14.81)0.700108 (66.67)54 (33.33)0.383
Negative8 (57.14)5 (35.71)1 (7.14)21 (75.00)7 (25.00)
RFPositive37 (45.12)30 (36.59)15 (18.29)0.152104 (63.41)60 (36.59)0.051
Negative10 (62.50)6 (37.50)026 (81.25)6 (18.75)
rs4821544T/CAnti-CCPPositive60 (74.07)21 (25.93)00.031141 (87.04)21 (12.96)0.043
Negative14 (100.00)0028 (100.00)0
RFPositive61 (74.39)21 (25.61)00.090143 (87.20)21 (12.80)0.113
Negative15 (93.75)1 (6.25)031 (96.88)1 (3.13)
rs729749C/TAnti-CCPPositive38 (46.91)28 (34.57)15 (18.52)0.533104 (64.20)58 (35.80)0.723
Negative7 (50.00)3 (21.43)4 (28.57)17 (60.71)11 (39.29)
RFPositive35 (42.68)31 (37.80)16 (19.51)0.279101 (61.59)63 (38.41)0.269
Negative10 (62.50)3 (18.75)3 (18.75)23 (71.88)9 (28.13)

M: major alleles; m: minor alleles.