Research Article
Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population
Table 2
Association of clinical characteristics with genotype and allele frequencies in
NCF2,
NCF4, and
CYBA genes among different groups (
(%)).
| SNP | Allele | Clinical features | Group | Genotypes (%) | value | Alleles (%) | value | (M/m) | MM | Mm | mm | M | m |
| All | rs10911363 | T/G | Anti-CCP | Positive | 128 (26.28) | 255 (52.36) | 104 (21.35) | 0.110 | 511 (52.46) | 463 (47.54) | 0.206 | Negative | 28 (37.33) | 31 (41.33) | 16 (21.33) | | 87 (58.00) | 63 (42.00) | | RF | Positive | 126 (26.30) | 256 (53.44) | 97 (20.25) | 0.122 | 508 (53.03) | 450 (46.97) | 0.806 | Negative | 30 (30.93) | 41 (42.27) | 26 (26.80) | | 101 (52.06) | 93 (47.94) | | rs3794624 | G/A | Anti-CCP | Positive | 346 (71.05) | 132 (27.10) | 9 (1.85) | 0.172 | 824 (84.60) | 150 (13.40) | 0.416 | Negative | 52 (69.33) | 19 (25.33) | 4 (5.33) | | 123 (82.00) | 27 (18.00) | | RF | Positive | 340 (70.98) | 128 (26.72) | 11 (2.30) | 0.682 | 808 (84.34) | 150 (15.66) | 0.946 | Negative | 68 (70.10) | 28 (28.87) | 1 (1.03) | | 164 (84.54) | 30 (15.46) | | rs4673 | G/A | Anti-CCP | Positive | 421 (86.45) | 66 (13.55) | 0 | 0.238 | 908 (93.22) | 66 (6.78) | 0.257 | Negative | 61 (81.33) | 14 (28.67) | 0 | | 136 (90.67) | 14 (9.33) | | RF | Positive | 409 (85.39) | 69 (14.41) | 1 (0.21) | 0.904 | 887 (92.59) | 71 (7.41) | 0.925 | Negative | 83 (85.57) | 14 (14.43) | 0 | | 180 (92.78) | 14 (7.22) | | rs1883112 | A/G | Anti-CCP | Positive | 241 (49.49) | 201 (41.27) | 45 (9.24) | 0.880 | 683 (70.12) | 291 (29.88) | 0.976 | Negative | 36 (48.00) | 33 (44.00) | 6 (8.00) | | 105 (70.00) | 45 (30.00) | | RF | Positive | 238 (49.69) | 192 (40.08) | 49 (10.23) | 0.076 | 668 (69.73) | 290 (30.27) | 0.697 | Negative | 45 (46.39) | 48 (49.48) | 4 (4.12) | | 138 (71.13) | 56 (28.87) | | rs4821544 | T/C | Anti-CCP | Positive | 384 (78.85) | 99 (20.33) | 4 (0.82) | 0.598 | 867 (89.01) | 107 (10.99) | 0.392 | Negative | 62 (82.67) | 13 (17.33) | 0 | | 137 (91.33) | 13 (8.67) | | RF | Positive | 378 (78.91) | 97 (20.25) | 4 (0.84) | 0.609 | 853 (89.04) | 105 (10.96) | 0.489 | Negative | 79 (81.44) | 18 (18.56) | 0 | | 176 (90.72) | 18 (9.28) | | rs729749 | C/T | Anti-CCP | Positive | 188 (38.60) | 215 (44.15) | 84 (17.25) | 0.820 | 591 (60.68) | 383 (39.32) | 0.754 | Negative | 29 (38.67) | 31 (41.33) | 15 (20.00) | | 89 (59.33) | 61 (40.67) | | RF | Positive | 183 (38.20) | 215 (44.89) | 81 (16.91) | 0.676 | 581 (60.65) | 377 (39.35) | 0.533 | Negative | 36 (37.11) | 41 (42.27) | 20 (20.62) | | 113 (58.25) | 81 (41.75) | | Female | rs10911363 | T/G | Anti-CCP | Positive | 86 (21.18) | 218 (53.69) | 102 (25.12) | 0.162 | 390 (48.03) | 422 (51.97) | 0.265 | Negative | 13 (21.31) | 26 (42.62) | 22 (36.07) | | 52 (42.62) | 70 (57.38) | | RF | Positive | 98 (24.69) | 220 (55.42) | 79 (19.9) | 0.074 | 416 (52.39) | 378 (47.61) | 0.680 | Negative | 24 (29.63) | 34 (41.98) | 23 (28.40) | | 82 (50.62) | 80 (49.38) | | rs3794624 | G/A | Anti-CCP | Positive | 283 (69.70) | 115 (28.33) | 8 (1.97) | 0.360 | 681 (83.87) | 131 (16.13) | 0.597 | Negative | 42 (68.85) | 16 (26.23) | 3 (4.92) | | 100 (81.97) | 22 (18.03) | | RF | Positive | 277 (69.77) | 110 (27.71) | 10 (2.52) | 0.750 | 664 (83.63) | 130 (16.37) | 0.919 | Negative | 56 (69.14) | 24 (29.63) | 1 (1.23) | | 136 (83.95) | 26 (16.05) | | rs4673 | G/A | Anti-CCP | Positive | 352 (86.70) | 54 (13.30) | 0 | 0.096 | 109 (89.34) | 13 (10.66) | 0.110 | Negative | 48 (78.69) | 13 (21.31) | 0 | | 758 (93.35) | 54 (6.65) | | RF | Positive | 341 (85.89) | 55 (13.85) | 1 (0.25) | 0.660 | 737 (92.82) | 57 (7.18) | 0.517 | Negative | 67 (82.72) | 14 (17.28) | 0 | | 148 (91.36) | 14 (8.64) | | rs1883112 | A/G | Anti-CCP | Positive | 202 (49.75) | 171 (42.12) | 33 (8.13) | 0.844 | 575 (70.81) | 237 (29.19) | 0.658 | Negative | 28 (45.90) | 28 (45.90) | 5 (8.20) | | 84 (68.85) | 38 (31.15) | | RF | Positive | 201 (50.63) | 162 (40.81) | 34 (8.56) | 0.151 | 564 (71.03) | 230 (28.97) | 0.629 | Negative | 35 (43.21) | 42 (51.85) | 4 (4.94) | | 112 (69.14) | 50 (30.86) | | rs4821544 | T/C | Anti-CCP | Positive | 324 (79.80) | 78 (19.21) | 4 (0.99) | 0.694 | 726 (89.41) | 86 (10.59) | 0.983 | Negative | 48 (78.69) | 13 (21.31) | 0 | | 109 (89.34) | 13 (10.66) | | RF | Positive | 317 (79.85) | 76 (19.14) | 4 (1.01) | 0.625 | 710 (89.42) | 84 (10.58) | 0.974 | Negative | 64 (79.01) | 17 (20.99) | 0 | | 145 (89.51) | 17 (10.49) | | rs729749 | C/T | Anti-CCP | Positive | 150 (36.95) | 187 (46.06) | 69 (17.00) | 0.978 | 487 (59.98) | 325 (40.02) | 0.840 | Negative | 22 (36.07) | 28 (45.90) | 11 (18.03) | | 72 (59.02) | 50 (40.98) | | RF | Positive | 148 (37.28) | 184 (46.35) | 65 (16.37) | 0.513 | 480 (60.45) | 314 (39.55) | 0.247 | Negative | 26 (32.10) | 38 (46.91) | 17 (20.99) | | 90 (55.56) | 72 (44.44) | | Male | rs10911363 | T/G | Anti-CCP | Positive | 26 (32.10) | 37 (45.68) | 18 (22.22) | 0.711 | 89 (54.94) | 73 (45.06) | 0.570 | Negative | 6 (42.86) | 5 (35.71) | 3 (21.43) | | 17 (60.71) | 11 (39.29) | | RF | Positive | 28 (34.15) | 36 (43.90) | 18 (21.95) | 0.948 | 92 (56.10) | 72 (43.90) | 0.732 | Negative | 6 (37.50) | 7 (43.75) | 3 (18.75) | | 19 (59.38) | 13 (40.63) | | rs3794624 | G/A | Anti-CCP | Positive | 63 (77.78) | 17 (20.99) | 1 (1.23) | 0.360 | 143 (88.27) | 19 (11.73) | 0.367 | Negative | 10 (71.43) | 3 (21.43) | 1 (7.14) | | 23 (82.14) | 5 (17.86) | | RF | Positive | 63 (76.83) | 18 (21.95) | 1 (1.22) | 0.880 | 144 (87.80) | 20 (12.20) | 0.962 | Negative | 12 (75.00) | 4 (25.00) | 0 | | 28 (87.50) | 4 (12.50) | | rs4673 | G/A | Anti-CCP | Positive | 69 (85.19) | 12 (14.81) | 0 | 0.441 | 150 (92.59) | 12 (7.41) | 0.458 | Negative | 13 (92.86) | 1 (7.14) | 0 | | 27 (96.43) | 1 (3.57) | | RF | Positive | 68 (82.93) | 14 (17.07) | 0 | 0.074 | 150 (91.46) | 14 (8.54) | 0.086 | Negative | 16 (100.00) | 0 | 0 | | 32 (100.00) | 0 | | rs1883112 | A/G | Anti-CCP | Positive | 39 (48.15) | 30 (37.04) | 12 (14.81) | 0.700 | 108 (66.67) | 54 (33.33) | 0.383 | Negative | 8 (57.14) | 5 (35.71) | 1 (7.14) | | 21 (75.00) | 7 (25.00) | | RF | Positive | 37 (45.12) | 30 (36.59) | 15 (18.29) | 0.152 | 104 (63.41) | 60 (36.59) | 0.051 | Negative | 10 (62.50) | 6 (37.50) | 0 | | 26 (81.25) | 6 (18.75) | | rs4821544 | T/C | Anti-CCP | Positive | 60 (74.07) | 21 (25.93) | 0 | 0.031 | 141 (87.04) | 21 (12.96) | 0.043 | Negative | 14 (100.00) | 0 | 0 | | 28 (100.00) | 0 | | RF | Positive | 61 (74.39) | 21 (25.61) | 0 | 0.090 | 143 (87.20) | 21 (12.80) | 0.113 | Negative | 15 (93.75) | 1 (6.25) | 0 | | 31 (96.88) | 1 (3.13) | | rs729749 | C/T | Anti-CCP | Positive | 38 (46.91) | 28 (34.57) | 15 (18.52) | 0.533 | 104 (64.20) | 58 (35.80) | 0.723 | Negative | 7 (50.00) | 3 (21.43) | 4 (28.57) | | 17 (60.71) | 11 (39.29) | | RF | Positive | 35 (42.68) | 31 (37.80) | 16 (19.51) | 0.279 | 101 (61.59) | 63 (38.41) | 0.269 | Negative | 10 (62.50) | 3 (18.75) | 3 (18.75) | | 23 (71.88) | 9 (28.13) | |
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M: major alleles; m: minor alleles.
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