Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis

Table 1

List of prioritized epitopes and their putative properties as well as their conservation in 296 spike protein sequences.

Epitopes	No. of HLA supertypes/alleles	HLA supertypes/alleles	Antigenicity score	Conservation level
FVFLVLLPL	4	A2, A26, B8, B62	0.8601	284/296
STQDLFLPF	4	A1, A24, A26, B62	0.6619	290/296
WTAGAAAYY	4	A1, A26, B58, B62	0.6306	292/296
YLQPRTFLL	4	A2, B8, B39, B62	0.4532	294/296
YQPYRVVVL	5	A2, A24, B8, B39, B62	0.5964	296/296
QIITTDNTF	4	A24, A26, B58, B62	0.4253	292/296
YFKIYSKHT	6	DRB10101, DRB10401, DRB10701, DRB10801, DRB11101, DRB11501	0.9056	296/296
GINITRFQTLLALHR	5	DRB10101, DRB10401, DRB10801, DRB11101, DRB11501	0.5582	292/296
FELLHAPAT	4	DRB10101, DRB10401, DRB11101, DRB11501	0.5409	290/296
YECDIPIGA	4	DRB10101, DRB10301, DRB10401, DRB10801	0.6385	294/296
SIIAYTMSLGAENSV	3	DRB10101, DRB10401, DRB10701	0.5691	291/296
FGAISSVLN	5	DRB10101, DRB10401, DRB10701, DRB10801, DRB11501	0.5435	296/296