Identification and Functional Analysis of EPOR⁺ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis

Table 2

Univariate and multivariate analyses of prognostic factors correlated to DFS and OS of patients with osteosarcoma lung metastases in this study ().

Variables	DFS				OS
	Univariate		Multivariate		Univariate		Multivariate
		HR	95% CI			HR	95% CI
Age (years) (<25 VS. ≥25)	0.196	—	—	—	0.285	—	—	—
Gender (male VS. female)	0.880	—	—	—	0.4703	—	—	—
Location of primary tumor (femur and tibia VS. other)	0.432	—	—	—	0.809	—	—	—
Size of primary tumor (cm) (≥5 VS. <5)	0.665	—	—	—	0.651	—	—	—
The number of lung metastases (multiple VS. <single)	<0.0001	2.7	1.62-4.2	<0.001	<0.0001	1.63	1.2-2.7	0.007
Maximal diameter of lung metastases (≥5 VS. <5)	0.060	—	—	—	0.070	—	—	—
Pathologic grade (well to moderately VS. poorly to undifferentiated)	<0.0001	3.4	1.6-6.9	0.001	<0.0001	2.3	1.3-4.1	0.006
Anemia (yes VS. no)	<0.0001	2.4	1.8-4.5	<0.001	<0.0001	1.8	1.2-2.65	0.005
The percentage of TAMs (≥2.5 VS. <2.5)	<0.0001	2.3	1.7-4.3	<0.001	<0.0001	1.6	1.1-2.7	0.003