Upregulation of FOXO3 in New-Onset Type 1 Diabetes Mellitus

Figure 1

FOXO3 expression analysis in type 1 diabetes. (a) FOXO3 is overexpressed in the type 1 diabetes group compared to healthy controls (, mean fold change 1.54). (b) Expression level of FOXO3 gene in the T1D group stratified according to the presence of initial diabetic ketoacidosis (DKA). The patients with diabetic ketoacidosis did not present statistically significant differences in FOXO3 expression compared to the patients without DKA (). Horizontal lines indicate median with range; asterisks indicate significance, with values estimated by unpaired -test; T1D: type 1 diabetes patients; C: controls; DKA(+): cohort of patients with initial diabetic ketoacidosis; DKA(-): cohort of patients without initial diabetic ketoacidosis.