Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis
Relationship between soluble Tyro3 levels, disease activity scores, and systemic disease parameters. Relationship between soluble Tyro3 (sTyro3), soluble Mer (sMer), and Gas6 levels in synovial fluid of RA patients () and disease activity scores based on erythrocyte sedimentation rate (DAS28-ESR) (a, d, g). sTyro3 levels in patients with low (<3.2), medium (3.2–4.0), and high (>4.0) DAS28ESR scores (b, e, h). Differences between soluble Tyro3 (sTyro3) in the synovial fluid of RA patients double positive (>10 IU/ml) for rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (ACPA) (16 samples), single positive for RF (2 samples) or ACPA (3 samples), and double negative (<10 IU/ml) (7 samples) (c, f, i). Data are presented as value for each comparison (unpaired -tests) or as Pearson value () and value () for correlation. ; .