Research Article
Association of High Calcitriol Serum Levels and Its Hydroxylation Efficiency Ratio with Disease Risk in SLE Patients with Vitamin D Deficiency
Table 2
Clinical characteristics by renal activity in SLE patients.
| Variable | Total | SLE patients | value | Renal activity | No renal activity |
| Age (years)a | 33 (20–59) | 32 (19–58) | 33 (20–59) | 0.44 | Disease evolution time % () | | | | 0.06 | >5 yearsb | 48 (41/85) | 33 (9/27) | 55 (32/58) | | SLICC ACR-DIa | 0 (0–04) | 1 (0–5) | 0 (0–3) | 0.02 | Damage (1)b | 39 (29/74) | 56 (13/23) | 31 (16/51) | 0.04 | Mex-SLEDAIa | 0 (0–8) | 2 (0–8) | 0 (0–7) | <0.01 | Clinical disease activity (≥2)b | 38 (33/87) | 58 (15/26) | 30 (18/61) | 0.01 | Renal insufficiencyb | 14 (12/83) | 37 (10/27) | 4 (2/56) | <0.001 | Serum variables | | | | | ANAs (+)b | 94 (63/67) | 96 (24/25) | 93 (39/42) | 0.60 | Anti-dsDNA (+)b | 59 (36/61) | 82 (18/22) | 46 (18/39) | <0.01 | C3 (mg/dL)a | 114 (55.3–150) | 75 (55.3–120) | 115 (1.17–156) | 0.03 | C4 (mg/dL)c | | | | 0.43 | Calcidiol reference values % () | | | | 0.03 | Sufficiency (≥30 ng/mL)b | 24 (20/82) | 27 (7/26) | 21 (13/61) | | Insufficiency (≥20 to <30 ng/mL)b | 43 (35/82) | 23 (6/26) | 52 (32/61) | | Deficiency (<20 ng/mL)b | 33 (27/82) | 50 (13/26) | 26 (16/61) | | Calcitriol tertiles % () | | | | 0.03 | (≥48.7 to 157.3 pg/mL)b | 24 (21/88) | 41 (11/27) | 16 (10/61) | | (≥33.6 to <48.7 pg/mL)b | 49 (43/88) | 44 (12/27) | 51 (31/61) | | (0.33 to <33.6 pg/mL)b | 27 (24/88) | 15 (4/27) | 33 (20/61) | | Calcitriol/calcidiol ratio tertiles % () | | | | 0.26 | (≥2.23 to 23.6 pg/ng)b | 29 (25/87) | 38 (10/26) | 25 (15/61) | | (≥1.36 to ≤2.23 pg/ng)b | 41 (36/87) | 42 (11/26) | 41 (25/61) | | (0.01 to <1.36 pg/ng)b | 30 (26/87) | 19 (5/26) | 34 (21/61) | | Serum calcium (mg/dL)c | | | | 0.43 |
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aData provided in medians (percentile: – ), Mann–Whitney test. bData provided in percentages ( /total patients), . cData provided in , Student -test. The bold letters indicate the variables with significant differences. SLICC: Systemic Lupus International Collaborating Clinics, American College of Rheumatology Damage Index; Mex-SLEDAI: Mexican Systemic Lupus Erythematosus Disease Activity Index; ANAs: antinuclear antibodies; Anti-dsDNA: anti-double-stranded DNA antibodies; C3 and C4: complement; GFR: glomerular filtration rate; G1: normal or high; G2: mildly decrease; G3a: mildly to moderately decrease; G3b: moderately to severely decrease; G4: severely decreased; G5: kidney failure. |