circ_0001588 Induces the Malignant Progression of Hepatocellular Carcinoma by Modulating miR-874/CDK4 Signaling

Figure 5

CDK4 was targeted by miR-874. (a, b) mRNAs regulated by miR-874. HCC cells were infected with miR-874 mimics. (c) The putative binding sites between miR-874 and CDK4 and the mutant sites in the CDK4-MUT reporter were displayed. (d, e) Luciferase activity was evaluated in HCC cells cotransfected with CDK4-MUT or CDK4-WT reporter and miR-874 inhibitors or mimics. (f, g) CDK4 expression HCC cells transfected with miR-874 mimics. .

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