SLAM/SAP Decreased Follicular Regulatory T Cells in Patients with Graves’ Disease

Figure 1

The expression of SLAM and SAP in the peripheral blood of the patients with GD and the healthy controls. The levels of (a) SAP mRNA and (b) SLAM mRNA in circulating CD4⁺ T cells from the patients with GD and the healthy controls. The mean fluorescence intensity (MFI) of SAP was analyzed by flow cytometry (FCM) in circulating (c) CD4⁺ T cells and (d) CD4⁺CXCR5⁺ T cells from the patients with GD and the healthy controls. The MFI of SLAM was analyzed by FCM on circulating (e) CD4⁺ T cells and (f) CD4⁺CXCR5⁺ T cells from the patients with GD and the healthy controls. (g) The MFI of SLAM was analyzed by FCM on circulating CD19⁺ B cells from the patients with GD and the healthy controls. Each data point represents an individual subject; horizontal lines show the mean. , ; ns: no significant differences.

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