Effect of Prophylactic Vaccination with the Membrane-Bound Acid Phosphatase Gene of Leishmania mexicana in the Murine Model of Localized Cutaneous Leishmaniasis
Footpad swelling (a), weight of lesions (b), and parasite burden (c) in BALB/c mice immunized and challenged with promastigotes of L. mexicana. Mice were immunized three times (intervals of 15 days between doses) with pVAX1::LmxMBA, pVAX1, or PBS. The results are expressed as of ten mice per group (a). The weight of the lesion was determined by amputation of the paw 105 days after the infection; the difference between the infected and healthy paws was taken as the net weight of the lesion (b). The number of parasites in the lesion was determined by limiting dilution culture, and the results are expressed as log10 (c). .
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.