Research Article

Leukocytes from Patients with Drug-Sensitive and Multidrug-Resistant Tuberculosis Exhibit Distinctive Profiles of Chemokine Receptor Expression and Migration Capacity

Figure 1

Workflow of DS-TB and MDR-TB patient recruitment and follow-up. A total of 25 TB patients were enrolled, 14 with multidrug-resistant (MDR-TB) and 11 with drug-sensitive (DS-TB). The first group was maintained at baseline, 1 month, and 3 months of anti-TB therapy (moTBt). Then, three patients were sent back to their local health care center (LHCC), and the number of patients decreased to 11 at 8 moTBt. Furthermore, one patient died of septic shock. Thus the MDR-TB cohort at 16 moTBt included 10 patients (left). The cohort of DS-TB patients was also maintained from baseline to 1 moTBt, but at 3 moTBt, two patients were sent back to their LHCC. Thus, the DS-TB cohort at 6 moTBt included 9 patients (right). Cells from two DS-TB patients were used to cell phenotype and migration assay because of the low number of cells yielded.