Research Article

Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver

Figure 7

Schematic representation depicting the potential mechanisms of Hv (hepatic vagotomy) aggravating hepatic ischemia-reperfusion injury. Expression of IL-22 induced by IR injury in the liver was significantly downregulated when the hepatic vagus branch was cut off. Following this, the activation of STAT3 signaling pathway is downregulated, and then the expression of cyclin D1 is downregulated, which eventually aggravates liver injury. In mice treated with exogenous IL-22, the aggravating effect of Hv on liver injury was reversed due to the IL-22 supplementation.