Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
Table 1
Polymorphism at HLA-A, -C, -B, and -DRB1 loci in the Croatian population (): heterozygosity parameters and categorization according to the EFI CWD catalogue18.
Region
Locus HLA-
Number of alleles
Heterozygosity
Total
COM#
WD#
Non-CWD
Obs
Exp
value (overall)1
Zagreb ()
A
33
27
4
2
2498
2512.44
0.7733
0.1976
C
30
24
3
3
2694
2661.49
0.5285
0.1723
B
67
51
8
8
2803
2783.14
0.7066
0.8336
DRB1
47
38
4
5
2716
2729.20
0.8005
0.0820
Dalmatia ()
A
31
26
4
1
1315
1321.02
0.8684
0.1563
C
28
24
3
1
1411
1385.08
0.4861
0.4134
B
58
47
6
5
1443
1444.37
0.9713
0.6171
DRB1
41
35
3
3
1424
1423.30
0.9851
0.0449
Istria & Primorje ()
A
31
27
2
2
755
750.29
0.8633
0.5863
C
28
24
2
2
784
782.15
0.9473
0.1225
B
54
48
3
3
816
818.74
0.9238
0.6098
DRB1
39
35
1
3
809
804.72
0.8801
0.7262
Central Croatia ()
A
29
25
1
3
875
877.56
0.9312
0.1421
C
28
25
2
1
936
928.49
0.8052
0.1935
B
63
51
7
5
980
970.34
0.7565
0.7258
DRB1
39
35
1
3
932
950.82
0.5416
0.0238
North Croatia ()
A
30
26
2
2
884
890.47
0.8284
0.9194
C
26
23
2
1
963
952.85
0.7424
0.0628
B
53
44
3
6
998
994.55
0.9129
0.9486
DRB1
41
36
3
2
971
969.97
0.9736
0.9290
East Croatia ()
A
38
29
4
5
1623
1621.34
0.9672
0.0873
C
27
24
2
1
1683
1700.18
0.6769
0.2344
B
70
51
7
10
1780
1782.94
0.9445
0.1501
DRB1
41
36
3
2
1741
1746.54
0.8946
0.0305
Legend: : number of tested individuals; : number of observed HLA alleles; Het Obs: observed heterozygosity; Het Exp: expected heterozygosity; #COM: common alleles according to the EFI catalogue; #WD: well-documented alleles according to the EFI catalogue18; 1overall value for the Guo and Thompson HW test.
