Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis

Figure 6

Treatment of P. brasiliensis infected mice with α-GalCer, an iNKT specific agonist, enhances host resistance to P. brasiliensis infection. WT C57BL/6 mice were infected with Pb18 yeasts and treated four weeks later with 10 μg of α-GalCer by the i.v. route. At week 8 after infection, the number of inflammatory cells in the BAL and the number of viable yeasts in the lung parenchyma of α-GalCer-treated and untreated mice were determined. (a) Total number of inflammatory cells in BAL. (b) Mononuclear and neutrophil cell counts in the airways. (c) Fungal loads in lung parenchyma. Data represent the from 1 independent experiment (/group). .

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(b)

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