Research Article
Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis
Table 1
The clinical characteristics of ccRCC patients between the high GSDMB expression group and low expression group.
| Characteristic | Low expression of GSDMB | High expression of GSDMB | |
| | 269 | 270 | | T stage, (%) | | | 0.040 | T1 | 154 (28.6%) | 124 (23%) | | T2 | 33 (6.1%) | 38 (7.1%) | | T3 | 79 (14.7%) | 100 (18.6%) | | T4 | 3 (0.6%) | 8 (1.5%) | | N stage, (%) | | | 0.593 | N0 | 115 (44.7%) | 126 (49%) | | N1 | 6 (2.3%) | 10 (3.9%) | | M stage, (%) | | | 0.358 | M0 | 225 (44.5%) | 203 (40.1%) | | M1 | 36 (7.1%) | 42 (8.3%) | | Pathologic stage, (%) | | | 0.093 | Stage I | 150 (28%) | 122 (22.8%) | | Stage II | 28 (5.2%) | 31 (5.8%) | | Stage III | 52 (9.7%) | 71 (13.2%) | | Stage IV | 38 (7.1%) | 44 (8.2%) | | Primary therapy outcome, (%) | | | 0.861 | PD | 5 (3.4%) | 6 (4.1%) | | SD | 4 (2.7%) | 2 (1.4%) | | PR | 1 (0.7%) | 1 (0.7%) | | CR | 76 (51.7%) | 52 (35.4%) | | Gender, (%) | | | 0.433 | Female | 88 (16.3%) | 98 (18.2%) | | Male | 181 (33.6%) | 172 (31.9%) | | Race, (%) | | | 0.057 | Asian | 1 (0.2%) | 7 (1.3%) | | Black or African American | 25 (4.7%) | 32 (6%) | | White | 239 (44.9%) | 228 (42.9%) | | Age, (%) | | | 0.064 | ≤60 | 123 (22.8%) | 146 (27.1%) | | >60 | 146 (27.1%) | 124 (23%) | | Histologic grade, (%) | | | 0.324 | G1 | 6 (1.1%) | 8 (1.5%) | | G2 | 126 (23.7%) | 109 (20.5%) | | G3 | 99 (18.6%) | 108 (20.3%) | | G4 | 32 (6%) | 43 (8.1%) | | Serum calcium, (%) | | | 0.446 | Elevated | 3 (0.8%) | 7 (1.9%) | | Low | 104 (28.4%) | 99 (27%) | | Normal | 75 (20.5%) | 78 (21.3%) | | Hemoglobin, (%) | | | 0.073 | Elevated | 2 (0.4%) | 3 (0.7%) | | Low | 125 (27.2%) | 138 (30.1%) | | Normal | 111 (24.2%) | 80 (17.4%) | | Laterality, (%) | | | 0.012 | Left | 111 (20.6%) | 141 (26.2%) | | Right | 158 (29.4%) | 128 (23.8%) | | OS event, (%) | | | <0.001 | Alive | 203 (37.7%) | 163 (30.2%) | | Dead | 66 (12.2%) | 107 (19.9%) | | DSS event, (%) | | | 0.006 | Alive | 224 (42.4%) | 196 (37.1%) | | Dead | 41 (7.8%) | 67 (12.7%) | | PFI event, (%) | | | 0.140 | Alive | 197 (36.5%) | 181 (33.6%) | | Dead | 72 (13.4%) | 89 (16.5%) | | Age, median (IQR) | 61 (53, 70) | 60 (51, 69) | 0.351 |
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ccRCC: clear cell renal cell carcinoma.
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