TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer

Figure 1

FUBP1 is upregulated and correlated with a poor prognosis in cervical cancer. (a) Analysis of FUBP1 genetic expression across various human cancers using TCGA databases. (b–e) Expression profiles of FUBP1 in cervical cancer (CC) and normal cervix (NC) samples from GSE6791 (b), GSE7410 (c), GSE7803 (d), and GSE9750 (e) datasets. (f) Expression profiles of FUBP1 in FIGO from TCGA databases. (g) Kaplan-Meier analysis of the overall survival of patients with FUBP1 high or low expression level. (h) Representative immunohistochemical images and quantification analysis showing FUBP1 expression in CC and paracarcinoma samples from the sixth hospital. (i, j) The mRNA (i) and protein levels (j) in different CC cell lines. Scale bar: 50 μm. Two-tailed -test, .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)