Expression of Killer Immunoglobulin Receptor Genes among HIV-Infected Individuals with Non-AIDS Comorbidities
Table 6
The relationship between KIR genes and non-AIDS associated comorbid conditions.
KIR genes
Diabetes
Hyperlipidemia
Hypertension
CVD
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
Inhibitory KIRs
KIR2DL1
1
—
0.3 (0.01-4.8)
0.362
0.1 (0.01-1.78)
0.129
0.08 (0.01-0.69)
0.022
KIR2DL2
1.1 (0.19-6.65)
0.886
0.5 (0.16-1.4)
0.179
1.3 (0.4-4.29)
0.664
1.04 (0.25-4.31)
0.954
KIR2DL3
1
—
0.7 (0.12-4.29)
0.721
0.08 (0.006-0.99)
0.05
0.2 (0.03-1.46)
0.113
KIR2DL5
2.3 (0.3-17.48)
0.422
1.3 (0.42-3.97)
0.651
1.9 (0.51-7.12)
0.341
0.6 (0.13-2.6)
0.476
KIR3DL1
0.14 (0.01-2.05)
0.151
0.4 (0.08-2.06)
0.272
0.6 (0.1-3.01)
0.493
1
—
Activating KIRs
KIR2DS1
2.1 (0.32-13.7)
0.44
1.4 (0.49-3.8)
0.555
2.7 (0.76-9.35)
0.124
0.8 (0.2-3.29)
0.759
KIR2DS2
1.1 (0.19-6.64)
0.886
0.5 (0.16-1.4)
0.179
1.3 (0.4-4.29)
0.664
1.04 (0.25-4.31)
0.954
KIR2DS3
2.4 (0.39-15.42)
0.34
1.2 (0.42-3.54)
0.715
1.6 (0.43-5.68)
0.501
0.2 (0.02-1.83)
0.11
KIR2DS4
0.14 (0.01-2.05)
0.151
0.4 (0.08-2.06)
0.272
0.6 (0.1-3.01)
0.493
1
—
KIR2DS5
2.3 (0.36-14.35)
0.377
1.03 (0.37-2.85)
0.962
1.8 (0.53-5.75)
0.355
1.04 (0.25-4.26)
0.962
KIR3DS1
2.5 (0.39-15.45)
0.34
1.7 (0.6-4.83)
0.32
2.6 (0.75-9.15)
0.131
0.6 (0.14-2.67)
0.507
Pseudogenes
KIR2DP1
1
—
0.3 (0.01-4.77)
0.362
0.14 (0.01-1.78)
0.129
0.08 (0.01-0.69)
0.022
CVD: cardiovascular disease; OR: odds ratio; 95% CI: 95% confidence interval. We adjusted for age, sex, and family history of comorbid condition. For hypertension and CVD, we also adjusted for smoking and alcohol use. We applied Bonferroni correction, and thus, values of <0.004 were considered significant.
