Copy Number Variation and Frequency of rs179008 in TLR7 Gene Associated with Systemic Lupus Erythematosus in Two Mexican Populations

Table 2

Association analysis of the allelic and genotypic frequencies of rs179008 (A>T) in SLE patients and healthy controls from Yucatán and Central Mexico.

Location	Allele and genotype	SLE patients	HW	Healthy controls	HW	OR	95% IC
Yucatán	A	168 (84%)		154 (75%)		Reference
						0.58	0.3577-0.9620	3.4 -02
	T	32 (16%)		50 (25%)
	A/A	69 (69%)	0.45	58 (57%)	1	Reference
	A/T	30 (30%)		38 (37%)		0.66	0.3669-1.200	1.7 -01
	T/T	1 (1%)		6 (6%)		0.14	0.0163-1.1974	7.3 -02
Central Mexico	A	152 (50%)		148 (61%)		Reference
						1.55	1.1025-2.1896	1.2 -02
	T	150 (50%)		94 (39%)
	A/A	5 (3%)	< 0.0001	30 (25%)	< 0.0001	Reference
	A/T	140 (93%)		88 (73%)		9.54	3.5696-25.5252	< 1.0 -04
	T/T	6 (4%)		3 (2%)		12	2.2400-64.2865	3.7 -03