Research Article

Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma

Figure 5

Genomic alteration features of the cuproptosis-relevant lncRNA signature. (a) Waterfall plot illustrating the first 20 mutated genes in high-risk subset. Statistical plots of mutation events for each mutated gene are exhibited in the right panel. Variant classifications are labeled by unique colors. (b) Waterfall plot depicting the first 20 mutated genes in low-risk subset. (c, d) Significant focal copy-number gains (red) and losses (blue) in high-risk subset. (e, f) Significant focal copy-number gains and losses in low-risk subset. (g) Distribution of fraction of genome altered, lost, and gained in low- and high-risk subsets. (h–m) Comparison of TMB, SNV neoantigens, aneuploidy score, CTA score, homologous recombination defects, and intratumor heterogeneity between two subsets. ; ; .
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