High Expression of PDLIM2 Predicts a Poor Prognosis in Prostate Cancer and Is Correlated with Epithelial-Mesenchymal Transition and Immune Cell Infiltration

Figure 6

PDLIM2 mRNA is involved in EMT process in prostate cancer patients. (a) The mRNA expression level of PDLIM2 was correlated with various EMT signatures and EMT-related genes. EMT_1, Chen et al. 2013; EMT_2, Klarmann et al. 2009; EMT_3, Mathews et al. 2010; EMT_4, Schell et al. 2016; EMT_5, Sethi et al. 2010; EMT_6, Stylilanou et al. 2019. (b) Heatmap showing the relationship between EMT signature-related genes and PDLIM2 expression. (c) Kaplan–Meier survival analysis showed the EMT signature reported by Mathews et al. was significantly associated with poor PFI in patients with prostate cancer. (d–i) The correlation between PDLIM2 mRNA expression land EMT biomarkers, including TJP1, DSP, VIM, CDH1, OCLN, and MMP2 in prostate cancer patients.

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