IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING

Figure 3

IL6 activates IRF3 through the cGAS-STING pathway. (a) Western blot of cGAS, STING, and pSTING treated with NC, IL6, or IL6 and NAC, respectively. (b) qRT-PCR analysis of IFN-α and IFN-β treated with NC, IL6, or IL6 and sh-STING, respectively. (c) qRT-PCR analysis of IRF3 treated with NC, IL6, or IL6 and sh-STING, respectively. (d) Western blot of TBK1, pTBK1, IRF3, and pIRF3 treated with NC, IL6, or IL6 and sh-STING, respectively. (e) Western blot of PD-L1 treated with NC, IL6, or IL6 and sh-STING, respectively. The data were represented as the ; or .

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