IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING

<div>IL6 contribute to immune escape via promote PD-L1 on EC cells-derived EVs <i>in vivo</i>. (a) qRT-PCR analysis of cytosolic DNA (mtDNA) in mouse serum EVs treated with PBS or IL6 treatment, respectively. (b) The PD-L1 content in mouse serum EVs treated with PBS or IL6 treatment was determined by ELISA, respectively. (c) Tumor volume was calculated every 7 days after injection treated with EVs/IL6 or anti-PD-L1-masking EVs/IL6. (d) Tumor weight was calculated after tumor excision EVs/IL6 or anti-PD-L1-masking EVs/IL6. (e) Immunofluorescence staining of CD3 and CD8 in resected tumor of mice EVs/IL6 or anti-PD-L1-masking EVs/IL6. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING 