Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer

Figure 5

LMAN2 is associated with homologous recombination (HR). (a) HR panel of 16 genes expresses differences in HER2 subtypes. (b) The LMAN2 expression is inversely linked to that of BRCA2, MRE11, and BRIP1. (c) The prognostic analysis shows that BRIP1 has a meaningful prognosis in HER2 subtypes. (d) The HR-associated proteins SLX4, RAD51D, BLM, PALB2, CHEK2, BRIP1, BRCA2, MRE11A, BRCA1, NBN, BARD1, RAD51C, ATR, RBBP8, MRE11, XRCC2, and LMAN2 were used to construct an advanced prognostic model. The lambda parameter displays the coefficients of several characteristics that have been chosen. The LASSO Cox regression model was utilized to plot the partial likelihood deviance vs. log (). The prognostic analysis of gene signature in TCGA set. The dashed line indicates the median risk score and classifies the patients into 2 groups: those at low risk and those at high risk (; ; ).

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