Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer

Table 1

Univariate and multivariate analyses of factors associated with LMAN2 survival.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	1079
T1 & T2	905	Reference
T3 & T4	174	1.608 (1.110-2.329)	0.012	2.361 (1.081-5.157)	0.031
N stage	1063
N0 & N1	871	Reference
N2 & N3	192	2.163 (1.472-3.180)	<0.001	1.614 (0.570-4.573)	0.367
M stage	922
M1	20	Reference
M0	902	0.235 (0.136-0.405)	<0.001	0.390 (0.120-1.269)	0.118
LMAN2	1082	1.009 (0.779-1.308)	0.944
Race	993
White	753	Reference
Asian	60	0.754 (0.239-2.383)	0.631
Black or African American	180	1.151 (0.765-1.731)	0.501
Age	1082
≤60	601	Reference
>60	481	2.020 (1.465-2.784)	<0.001	3.810 (2.028-7.159)	<0.001
PR status	1029
Negative	342	Reference
Positive	687	0.732 (0.523-1.024)	0.068	0.756 (0.311-1.842)	0.539
ER status	1032
Negative	240	Reference
Positive	792	0.712 (0.495-1.023)	0.066	0.486 (0.190-1.243)	0.132
HER2 status	715
Negative	558	Reference
Positive	157	1.593 (0.973-2.609)	0.064	0.786 (0.371-1.664)	0.529
Pathologic stage	1059
Stage I & stage II	799	Reference
Stage III & stage IV	260	2.391 (1.703-3.355)	<0.001	2.760 (0.859-8.862)	0.088
Radiation therapy	986
No	434	Reference
Yes	552	0.576 (0.394-0.841)	0.004	0.475 (0.249-0.904)	0.023