C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats

Figure 7

Macrophage and osteoclast activities and photomicrographs of immunopositive cells in the synovium and cartilage. (a)–(d) The IHC results of CD68 expression in the synovial membrane from Con, CFA, CRP, and groups, respectively. (e)–(h) The IHC results of iNOS from Con, CFA, CRP, and groups, respectively. (i)–(l) The IHC results of RANKL expression in the TMJ cartilage from Con, CFA, CRP, and groups, respectively. (m)–(p) TRAP staining of subchondral bone from Con, CFA, CRP, and groups, respectively. (q)–(s) Semiquantitative analysis of (a)–(l). (t) Statistical results of TRAP-positive cells (clusters of more than 3 nuclei were counted as one osteoclast) in the different groups. (; ; ).

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