Characterization of m6A Methylation Modification Patterns in Colorectal Cancer Determines Prognosis and Tumor Microenvironment Infiltration

Figure 2

Relationship between m6A regulator expression and tumor immune cell infiltration in The Cancer Genome Atlas-colorectal cancer (TCGA-CRC) dataset. (a) Correlation and prognosis network of 21 m6A regulators in patients with CRC. (b) Correlation heat map between immune cell infiltrates and 21 m6A regulator expression. (c) Gene set enrichment analysis (GSEA) for high and low YTHDC2 expression status. (d) Correlation between overall survival (OS) and YTHDC2 expression in TCGA-CRC cohort (log-rank test, ). (e) Correlation between OS and YTHDC2 expression in IMvigor210 cohort (log-rank test, ). (f) Differences in YTHDC2 expression across anatomical locations in TCGA-CRC dataset. (g) Differences in YTHDC2 expression and tumor mutational burden in TCGA-CRC dataset. (h) A boxplot showing relative YTHDC2 expression in different clinical response groups.

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