Journal of Immunology Research

The Tumour Microenvironment and Immunity


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
16 Apr 2021

Lead Editor

1Shanghai Jiao Tong University, Shanghai, China

2China Medical University, Shenyang, China

3The Affiliated Feng Xian Center Hospital of Southern Medical University, Shanghai, China

4Malmö Lund University, Lund, Sweden

This issue is now closed for submissions.
More articles will be published in the near future.

The Tumour Microenvironment and Immunity

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The rise of immunotherapy gives new prospects for a cure for cancer. However, in some nonimmunogenic tumours, immunotherapy has failed to demonstrate significant clinical activity, in part due to a complex tumour microenvironment (TME) that provides a formidable barrier to immune infiltration and function.

The TME, comprised of multiple cellular and molecular factors, significantly influences tumour progression and therapeutic response. The complex interactions among tumours, immune cells, and their microenvironment remain to be elucidated. Immune cells can play either a pro- or anti-tumour role and may vary in their activation status within the tumour microenvironment. Both innate immune cells and adaptive immune cells are present and interact with the tumour cells via direct contact or through chemokine and cytokine signalling, which shapes the behaviour of the tumour and its response to therapy. In addition, components of the TME also have a broad impact on the immune cells. Up to now, numerous evidence has been provided to suggest that the TME can alter the capacity of the immune system in tumours.

The aim of this Special Issue is to collate original research and review articles that will aid in uncovering the complex interactions between tumours, immune cells, and their microenvironment.

Potential topics include but are not limited to the following:

  • The spatial and temporal distribution of immune cells in TME
  • Cancer cell-immune cell interaction in TME
  • Endothelial cell-immune cell interaction in TME
  • Fibroblast-immune cell interaction in TME
  • Immune cell-extracellular matrix interaction in TME
  • Immune cells in the premetastatic niche
  • Crosstalk between the nervous system and TME
  • Crosstalk between the endocrine system and TME
  • Crosstalk among immune cells
  • Clinical perspectives of TME and immune niches

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 5523832
  • - Research Article

A Hypoxia Gene-Based Signature to Predict the Survival and Affect the Tumor Immune Microenvironment of Osteosarcoma in Children

Feng Jiang | Xiao-Lin Miao | ... | Guo-Ping Zhou
  • Special Issue
  • - Volume 2021
  • - Article ID 9920234
  • - Research Article

Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression

Mieszko Lachota | Anton Lennikov | ... | Radoslaw Zagozdzon
  • Special Issue
  • - Volume 2021
  • - Article ID 5564568
  • - Research Article

An Immune-Related Prognostic Classifier Is Associated with Diffuse Large B Cell Lymphoma Microenvironment

Xiao-Jie Liang | Rui-ying Fu | ... | Liang Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 9972927
  • - Review Article

Natural Killer Cell Dysfunction in Obese Patients with Breast Cancer: A Review of a Triad and Its Implications

Esraa Elaraby | Abdullah Imadeddin Malek | ... | Iman M. Talaat
  • Special Issue
  • - Volume 2021
  • - Article ID 6636791
  • - Research Article

DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis

Leilei Xia | Ye Wang | ... | Mingjuan Xu
  • Special Issue
  • - Volume 2021
  • - Article ID 9958239
  • - Research Article

Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy

Xiang Li | Zhen Wang | ... | Zhong Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 6649314
  • - Review Article

Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells

Kimberly Thando Peta | Melvin Anyasi Ambele | Michael Sean Pepper
  • Special Issue
  • - Volume 2021
  • - Article ID 5580672
  • - Research Article

Norepinephrine Enhances Aerobic Glycolysis and May Act as a Predictive Factor for Immunotherapy in Gastric Cancer

Yangyang Wang | Shuchang Wang | ... | Enhao Zhao
  • Special Issue
  • - Volume 2021
  • - Article ID 8875450
  • - Research Article

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6

Huan Yi | Yan-zhao Su | ... | Rong Zhang
  • Special Issue
  • - Volume 2021
  • - Article ID 6618837
  • - Research Article

Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway

Manzila Kuerbanjiang | Lei Gu | ... | Qing Xu
Journal of Immunology Research
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