Journal of Immunology Research

Peptide-Based Immunotherapeutics and Vaccines 2017


Status
Published

Lead Editor

1Universidad Complutense de Madrid, Madrid, Spain

2Aston University, Birmingham, UK

3LLC, Worcester, USA

4National Institute of Infectious Diseases, Tokyo, Japan


Peptide-Based Immunotherapeutics and Vaccines 2017

Description

An improved understanding of antigen presentation and recognition has enabled the development of new types of vaccines and immunotherapies based on synthetic peptides encompassing B- and T-cell epitopes. The design of such vaccines takes advantage of emergent computational and experimental technologies that facilitate the identification of epitopes within protein antigens.

Peptide-based vaccines offer several advantages over traditional vaccines. Chiefly, they allow the immune response to focus solely on relevant epitopes, avoiding those that lead to nonprotective responses, immune evasion, or unwanted side effects, such as autoimmunity. However, the development of effective peptide-based vaccines requires overcoming significant difficulties, including identifying optimal delivery routes, overcoming the low immunogenicity of peptides, combining different type of epitopes to engage the humoral and cellular arms of the adaptive immune response, and compensating for the poor population coverage of individual T-cell epitopes due to MHC restriction. Moreover, certain antigenic epitopes, specifically B-cell epitopes, are conformational and need to be mimicked by linear sequences or placed onto suitable spatial frameworks.

We invite authors to submit original research and review articles addressing any of these issues in the development of peptide-based vaccines against infectious diseases, cancer, allergy, and autoimmune diseases.

Potential topics include but are not limited to the following:

  • New advances in epitope prediction and large-scale epitope discovery
  • Current progress in characterizing peptide repertoires presented by tumor and antigen presenting cells
  • New approaches for increasing peptide immunogenicity and optimizing the delivery of peptide-based vaccines
  • Development of peptide-based vaccines for the treatment of infectious diseases
  • Development of prophylactic and therapeutic peptide-based vaccines against cancer
  • Peptide-based immunotherapy for allergic and autoimmune diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 4568239
  • - Editorial

Peptide-Based Immunotherapeutics and Vaccines 2017

Pedro Reche | Darren R. Flower | ... | Yoshihiko Hoshino
  • Special Issue
  • - Volume 2018
  • - Article ID 4928757
  • - Research Article

Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients

Mamiko Niki | Takashi Yoshiyama | ... | Yoshihiko Hoshino
  • Special Issue
  • - Volume 2018
  • - Article ID 3497401
  • - Research Article

Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle

I. Soria | V. Quattrocchi | ... | P. Zamorano
  • Special Issue
  • - Volume 2018
  • - Article ID 5463879
  • - Research Article

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice

Jeannette Lo | Chang-Qing Xia | ... | Michael J. Clare-Salzler
  • Special Issue
  • - Volume 2018
  • - Article ID 7685371
  • - Research Article

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

V. S. Kichatova | K. K. Kyuregyan | ... | M. I. Mikhailov
  • Special Issue
  • - Volume 2017
  • - Article ID 2680160
  • - Review Article

Fundamentals and Methods for T- and B-Cell Epitope Prediction

Jose L. Sanchez-Trincado | Marta Gomez-Perosanz | Pedro A. Reche
  • Special Issue
  • - Volume 2017
  • - Article ID 9363750
  • - Research Article

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus

Julio Alonso-Padilla | Esther M. Lafuente | Pedro A. Reche
  • Special Issue
  • - Volume 2017
  • - Article ID 6412353
  • - Research Article

Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA

Arafat Rahman Oany | Tahmina Pervin | ... | K. M. Kaderi Kibria
  • Special Issue
  • - Volume 2017
  • - Article ID 7407136
  • - Research Article

Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice

Anastasia Latanova | Stefan Petkov | ... | Elizaveta Starodubova
  • Special Issue
  • - Volume 2017
  • - Article ID 5974574
  • - Review Article

The Immune Epitope Database: How Data Are Entered and Retrieved

Ward Fleri | Kerrie Vaughan | ... | Alessandro Sette
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision111 days
Acceptance to publication37 days
CiteScore3.330
Impact Factor3.404
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