Journal of Immunology Research

Natural Immunomodulators 2018


Publishing date
01 May 2019
Status
Published
Submission deadline
28 Dec 2018

1Universidad de Guadalajara, Guadalajara, Mexico

2Witten/Herdecke University, Witten, Germany

3CSIR-National Botanical Research Institute, Lucknow, India


Natural Immunomodulators 2018

Description

Natural compounds, a large majority coming from plant origin, have enormously contributed as immunomodulatory therapeutics. Since ancient times, natural medicines have always fascinated the humans, with their own qualities of harmless treatments with minimal side effects. There are thousands of natural compounds such as the compounds from plants like Curcuma longa, Viscum album, Allium sativum (garlic), and Calendula officinalis and their derivatives which are known to influence the immune system either by affecting the functions of immune cells like dendritic cells, macrophages, lymphocytes, and natural killer (NK) cells or by affecting the antibody secretion to control the infection and to maintain the immune homeostasis.

Immunomodulatory functions of these compounds include immunostimulation by activating the immune cells and increasing the proliferation of lymphocytes and secretion of immunostimulatory cytokines such as IL-1β, IFN-γ, IL-6, IL-12, and anti-inflammatory effects by inhibiting the proinflammatory cytokines and inhibiting the cellular activation and proliferation. Immunomodulatory functions also include the role of these natural compounds in regulating the immune responses by interfering with the tolerance mechanisms, thereby establishing an immune homeostasis. Therefore, it is interesting to dissect the immunomodulatory mechanisms of natural compounds and to discover the novel promising candidates that can be used in the future immunotherapeutic strategies.

An extensive future investigation is required with respect to their mechanisms of action at systemic, cellular, and molecular level to extend up to broad-spectrum clinical trials. Given the multiple biological effects of natural compounds, it is exceedingly interesting to design the future therapeutic strategies for inflammatory pathologies and malignant diseases with a synergistic combination of natural products together with various conventional therapies.

This special issue therefore is focusing on such natural immunomodulators, in order to provide the maximum proof of concept for their use, as natural medicines.

Potential topics include but are not limited to the following:

  • Identification of unknown novel therapeutic molecules or products of natural origin and their documentation
  • Identification of novel biological effects of known therapeutic natural compounds
  • Effects of natural compounds on the activation, cytokine secretion, and T cell stimulatory effects of dendritic cells and macrophages
  • Effects on activation and functions of basophils, eosinophils, and natural killer cells
  • Effects on T cell activation, proliferation, cytokine secretion, and T cell polarization
  • Effects on B cell activation, functions, and antibody secretion
  • Effects on the functions of regulatory T cells and immune tolerance
  • Antitumor properties of natural compounds
  • Effects on immune system during antitumor mechanisms
  • Anti-inflammatory properties of natural compounds on LPS induced inflammation
  • Molecular mechanisms and signaling pathways underlying these immunomodulatory effects
  • Studies on animal models and human cohorts
  • Combinational therapeutic approaches with natural compounds and other conventional therapies

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4341698
  • - Editorial

Natural Immunomodulators 2018

Daniel Ortuño-Sahagún | Ajay K. S. Rawat | Kurt Zänker
  • Special Issue
  • - Volume 2019
  • - Article ID 3783209
  • - Research Article

Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis

Rongjiong Zheng | Songsong Xie | ... | Kai Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 3062754
  • - Research Article

The Role of O-Antigen in LPS-Induced Activation of Human NK Cells

Leonid M. Kanevskiy | Sofya A. Erokhina | ... | Elena I. Kovalenko
  • Special Issue
  • - Volume 2019
  • - Article ID 2754920
  • - Research Article

Development of Functional Antibodies Directed to Human Dialyzable Leukocyte Extract (Transferon®)

Gabriela Mellado-Sánchez | Juan José Lázaro-Rodríguez | ... | Sonia Mayra Pérez-Tapia
  • Special Issue
  • - Volume 2019
  • - Article ID 1018274
  • - Research Article

Comparison of Inhibitory Effects of Safflower Decoction and Safflower Injection on Protein and mRNA Expressions of iNOS and IL-1β in LPS-Activated RAW264.7 Cells

Hui Liao | Yuanping Li | ... | Rongshan Li
  • Special Issue
  • - Volume 2019
  • - Article ID 3019794
  • - Research Article

Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB

José Roberto Macías-Pérez | Bruno Jesús Vázquez-López | ... | Javier Ventura-Juárez
  • Special Issue
  • - Volume 2019
  • - Article ID 6105059
  • - Clinical Study

A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults

Angélica Y. Gómez-Arauz | Nallely Bueno-Hernández | ... | Guillermo Meléndez
  • Special Issue
  • - Volume 2019
  • - Article ID 5763430
  • - Review Article

The Evolving Roles of Macrophages in Organ Transplantation

Junhui Li | Cai Li | ... | Yingzi Ming
  • Special Issue
  • - Volume 2019
  • - Article ID 7431652
  • - Research Article

Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2/HO-1 and NF-κB/IL-1β Signaling Pathways

José Roberto Macías-Pérez | Liseth Rubí Aldaba-Muruato | ... | Javier Ventura-Juárez
  • Special Issue
  • - Volume 2019
  • - Article ID 2198508
  • - Research Article

CD80 Expression Correlates with IL-6 Production in THP-1-Like Macrophages Costimulated with LPS and Dialyzable Leukocyte Extract (Transferon®)

Alexis P. Jiménez-Uribe | Hugo Valencia-Martínez | ... | Sonia M. Pérez-Tapia
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision60 days
Acceptance to publication36 days
CiteScore5.100
Impact Factor3.327
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