Journal of Immunology Research

Systemic Lupus Erythematosus: Genomics, Mechanisms, and Therapies


Publishing date
01 Nov 2011
Status
Published
Submission deadline
01 May 2011

1Department of Rheumatology, Carlos Haya Regional University Hospital, University of Málaga, 29009 Málaga, Spain

2Grup de Recerca de Reumatologia Institut de Recerca, Hospital Vall d'Hebron, 119-129 Barcelona, Spain

3Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35226, USA

4Centre for Rheumatology, University College London, London W1T 4JF, UK


Systemic Lupus Erythematosus: Genomics, Mechanisms, and Therapies

Description

Systemic lupus erythematosus (SLE) is one of the most diverse autoimmune diseases because it may affect multiple organs in the body and display a broad spectrum of clinical and immunological manifestations. Genome-wide association studies (WGASs) have confirmed the importance of genes associated with autoimmune response and inflammation, tissue response to injury, and adherence of inflammatory cells to the endothelium. Mechanisms related to both innate and acquired immunity and a thrombophilic state associated with antiphospholipid antibodies are crucial for mediating tissue dysfunction. Major advances in the understanding of these immunological abnormalities have made possible the development of new treatments in the last 10 years including novel combinations of immunosuppressive drugs and biological agents.

We invite authors to submit original research and review articles that contribute to improve the understanding of this disease and its treatment options. We are interested in articles related to the pathogenesis with particular emphasis on genetics and genomics, immune mechanisms that mediate both inflammation and hypercoagulability, and the most recent treatment strategies. Potential topics include, but are not limited to:

  • Genetics and genomics in SLE; WGASs and gene-gene interactions
  • Proteomics approach for assessing disease activity
  • Transcriptomics in SLE; renal and peripheral blood gene expression profile
  • Biomarkers in translational research studies in SLE
  • Biological agents in the treatment of SLE
  • Clinical trials in SLE; challenges and possible solutions
  • Pharmacogenomics in SLE; predictors of response
  • Risk prediction in SLE; classification and outcome
  • Race/ethnicity in SLE
  • Cardiovascular disease risk in patients with SLE
  • Preclinical animal models for SLE
  • Cellular and molecular mechanisms involved in SLE
  • Mechanisms of thrombosis in antiphospholipid syndrome (APS)
  • Mechanisms of pregnancy morbidity in APS
  • Prospects for new treatments to replace anticoagulant in APS

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 926931
  • - Editorial

Systemic Lupus Erythematosus: Genomics, Mechanisms, and Therapies

Antonio Fernández-Nebro | Sara Marsal | ... | Anisur Rahman
  • Special Issue
  • - Volume 2012
  • - Article ID 579670
  • - Review Article

Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

Guillaume Seret | Yannick Le Meur | ... | Pierre Youinou
  • Special Issue
  • - Volume 2012
  • - Article ID 694143
  • - Review Article

Imaging Assessment of Cardiovascular Disease in Systemic Lupus Erythematosus

Sara C. Croca | Anisur Rahman
  • Special Issue
  • - Volume 2012
  • - Article ID 548516
  • - Research Article

Deranged Bioenergetics and Defective Redox Capacity in T Lymphocytes and Neutrophils Are Related to Cellular Dysfunction and Increased Oxidative Stress in Patients with Active Systemic Lupus Erythematosus

Ko-Jen Li | Cheng-Han Wu | ... | Chia-Li Yu
  • Special Issue
  • - Volume 2012
  • - Article ID 198206
  • - Research Article

Phenotyping of P105-Negative B Cell Subsets in Patients with Systemic Lupus Erythematosus

Syuichi Koarada | Yoshifumi Tada | ... | Kohei Nagasawa
  • Special Issue
  • - Volume 2012
  • - Article ID 831434
  • - Clinical Study

Systemic Lupus Erythematosus and Systemic Autoimmune Connective Tissue Disorders behind Recurrent Diastolic Heart Failure

Luis Miguel Blasco Mata | Olga Acha Salazar | ... | Enrique Pérez-Llantada Amunárriz
  • Special Issue
  • - Volume 2012
  • - Article ID 963730
  • - Review Article

Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview

Hwa Chia Chai | Maude Elvira Phipps | Kek Heng Chua
  • Special Issue
  • - Volume 2012
  • - Article ID 259186
  • - Review Article

RP105-Negative B Cells in Systemic Lupus Erythematosus

Syuichi Koarada | Yoshifumi Tada
  • Special Issue
  • - Volume 2012
  • - Article ID 135932
  • - Review Article

Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

Giuliana Guggino | Anna Rita Giardina | ... | Guido Sireci
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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