Journal of Immunology Research

Complement in Human Disease


Publishing date
23 Nov 2012
Status
Published
Submission deadline
06 Jul 2012

1Department of Orthopaedic Surgery, School of Medicine, University of Colorado, Aurora, CO, USA

2Division of Trauma Surgery, Department of Surgery, University Hospital Zurich, Zurich, Switzerland

3Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany

4Department of Orthopaedic Surgery, Denver Health Medical Center, School of Medicine, University of Colorado, Denver, CO, USA


Complement in Human Disease

Description

Complement represents one of the phylogenetically oldest cascade systems. Nevertheless, we are only beginning to unravel the wide-ranging involvement of the complement system in human disease. As part of innate immunity, the complement system embodies the “first line of defense” to various initial insults, including trauma, infection, hemorrhage, ischemia, and autoimmunity. While of beneficial intention, excessive complement activation can inadvertently damage healthy host tissues and thereby exacerbate the initial pathological events by causing an “innocent bystander effect.” Over the last decades, our understanding of the complement system has rapidly evolved. Novel activation pathways aside from the traditional classical, alternative, and lectin pathway have been described. Furthermore, selective blockade of the complement activation products, complement receptors, or complement tissue deposition has been shown to ameliorate myriad inflammatory conditions. The development of novel pharmacological compounds selectively targeting the complement system has opened the way to promising novel strategies to advance the presently elusive translation from “bench to beside.”

This special issue will highlight review articles and original research articles exploring complement-induced pathophysiology in humans and experimental animal models and provide insights into innovative therapeutic approaches to ameliorate complement-driven disease. Potential topics include, but are not limited to:

  • Advances in understanding complement-induced pathophysiology and specific complement components in disease
  • Acute inflammatory conditions, infection, or mechanisms of danger sensing and transmission, and complement-mediated autoimmune disorders
  • Development and testing of novel therapeutic avenues targeting complement activation and/or complement deposition
  • Insights into the role of complement activation products as novel diagnostic mediators for determining the severity and prognosis in disease
  • Characterization of novel animal models mimicking complement-induced inflammatory conditions in humans
  • Advances in clinical trials targeting complement activation products to ameliorate complement-mediated pathology

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 920474
  • - Editorial

Complement in Human Disease

Michael A. Flierl | Daniel Rittirsch | ... | Philip F. Stahel
  • Special Issue
  • - Volume 2012
  • - Article ID 534291
  • - Review Article

Complement Activation and Inhibition in Wound Healing

Gwendolyn Cazander | Gerrolt N. Jukema | Peter H. Nibbering
  • Special Issue
  • - Volume 2012
  • - Article ID 187080
  • - Research Article

Dual Functions of the C5a Receptor as a Connector for the K562 Erythroblast-Like Cell-THP-1 Macrophage-Like Cell Island and as a Sensor for the Differentiation of the K562 Erythroblast-Like Cell during Haemin-Induced Erythropoiesis

Hiroshi Nishiura | Rui Zhao | Tetsuro Yamamoto
  • Special Issue
  • - Volume 2012
  • - Article ID 962927
  • - Review Article

Role of Complement in Multiorgan Failure

Daniel Rittirsch | Heinz Redl | Markus Huber-Lang
  • Special Issue
  • - Volume 2012
  • - Article ID 962702
  • - Review Article

Complement Diagnostics: Concepts, Indications, and Practical Guidelines

Bo Nilsson | Kristina Nilsson Ekdahl
  • Special Issue
  • - Volume 2012
  • - Article ID 354894
  • - Clinical Study

The Effect of Weight Loss on Serum Mannose-Binding Lectin Levels

P. H. Høyem | J. M. Bruun | ... | T. K. Hansen
  • Special Issue
  • - Volume 2012
  • - Article ID 695131
  • - Review Article

Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come

Saskia F. Heeringa | Clemens D. Cohen
  • Special Issue
  • - Volume 2012
  • - Article ID 370426
  • - Review Article

Familial Atypical Hemolytic Uremic Syndrome: A Review of Its Genetic and Clinical Aspects

Fengxiao Bu | Nicolo Borsa | ... | Richard J. H. Smith
  • Special Issue
  • - Volume 2012
  • - Article ID 307093
  • - Review Article

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

Sean R. Stowell | Anne M. Winkler | ... | Jeanne E. Hendrickson
  • Special Issue
  • - Volume 2012
  • - Article ID 407324
  • - Review Article

The Role of Complement System in Septic Shock

Jean Charchaflieh | Jiandong Wei | ... | Ming Zhang
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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