For decades, compounds derived from natural products have demonstrated their effectiveness as therapeutic agents in different areas, such as metabolic disorders, cardiovascular diseases, inflammation, and neurological disorders. Natural products, like herbal medicines, fatty acids, and probiotics, also are implicated in the regulation of immune function. They control over the immune system in a pleiotropic manner and participate in various processes of adaptive/innate immunity. Therefore, natural products have great potential for targeted immune modulators in the treatment of certain types of immunologic and inflammatory diseases, like rheumatoid arthritis, plaque psoriasis, ankylosing spondylitis, Crohn’s disease, and ulcerative colitis.

The aim of this Special Issue is to collate original research articles or literature reviews that explore novel aspects concerning the roles of natural products in the immune system and explore the potential treatment/target of immunologic and inflammatory diseases using natural products.

Potential topics include but are not limited to the following:

• Development and exploring novel natural products as immunomodulating agents
• Novel mechanisms of natural products in the regulation of immune response or inflammatory process
• Clinical or preclinical evaluation of natural products in the diagnosis and treatment of immune diseases.