Journal of Immunology Research

T-Regulatory Cells in Health and Disease


Publishing date
01 Aug 2018
Status
Published
Submission deadline
23 Mar 2018

Lead Editor
Guest Editors

1Qatar Biomedical Research Institute, Doha, Qatar


T-Regulatory Cells in Health and Disease

Description

T-regulatory cells (Tregs) are immunosuppressive cells that are essential for maintaining homeostasis and immune tolerance. Tregs are known to have well-characterized roles in various pathological settings including inflammation, autoimmunity, graft rejection, and cancer. Defects in Treg function lead to the development of numerous autoimmune disorders including autoimmune thyroid disease (AITD), immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and multiple sclerosis. Furthermore, Tregs accumulate in peripheral tissues and tumor microenvironment, where they suppress tumor-specific immune responses and contribute to the development of a tolerogenic tumor microenvironment that effectively enables tumors to evade the immune system. A better understanding of Tregs in various disease settings is critical to target these cells for therapeutic benefits.

The aim of this special issue is to provide a platform for researchers and scientists to share their research on the role and function of Tregs in health and different diseases. We are particularly interested in original research and review articles, which can provide new insights into the role and function of Tregs in health and human disease milieu.

Potential topics include but are not limited to the following:

  • Importance of Tregs for maintaining hemostasis and immune tolerance
  • Role of Tregs in inflammation, autoimmunity, transplantation, and cancer
  • Phenotype of Tregs in various human diseases
  • Epigenetic modifications of Tregs in various human diseases
  • Importance of targeting Tregs in various therapeutic modalities
  • Targeting Tregs in cancer immunotherapy
  • Gene mutations related to Tregs function in various disease settings
  • Essential function of FOXP3 in maintaining immune tolerance in various diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5025238
  • - Editorial

T-Regulatory Cells in Health and Disease

Eyad Elkord | Varun Sasidharan Nair
  • Special Issue
  • - Volume 2018
  • - Article ID 3758713
  • - Review Article

Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer

Martha R. Vieyra-Lobato | Jorge Vela-Ojeda | ... | Martha C. Moreno-Lafont
  • Special Issue
  • - Volume 2018
  • - Article ID 9627806
  • - Research Article

Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus

Marlen Vitales-Noyola | Esther Layseca-Espinosa | ... | Roberto González-Amaro
  • Special Issue
  • - Volume 2018
  • - Article ID 9325261
  • - Clinical Study

Impact of Bone Marrow Aspirate Tregs on the Response Rate of Younger Newly Diagnosed Acute Myeloid Leukemia Patients

Mario Delia | Paola Carluccio | ... | Giorgina Specchia
  • Special Issue
  • - Volume 2018
  • - Article ID 7271097
  • - Review Article

Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation

Naoki Hosaka
  • Special Issue
  • - Volume 2018
  • - Article ID 2484825
  • - Research Article

CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro

Nina Pilat | Benedikt Mahr | ... | Thomas Wekerle
  • Special Issue
  • - Volume 2018
  • - Article ID 4396351
  • - Review Article

Regulatory Role of CD4+ T Cells in Myocarditis

Daria Vdovenko | Urs Eriksson
  • Special Issue
  • - Volume 2018
  • - Article ID 3096183
  • - Research Article

The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients

Tiantian Chen | Xiaoxia Hou | ... | Guochao Shi
  • Special Issue
  • - Volume 2018
  • - Article ID 6012053
  • - Review Article

Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells

D. Calzada | S. Baos | ... | B. Cárdaba
  • Special Issue
  • - Volume 2018
  • - Article ID 1292404
  • - Research Article

CD4+CD25highCD127low/−FoxP3+ Regulatory T Cell Subpopulations in the Bone Marrow and Peripheral Blood of Children with ALL: Brief Report

M. Niedźwiecki | O. Budziło | ... | P. Trzonkowski
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision65 days
Acceptance to publication30 days
CiteScore3.330
Impact Factor3.404
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