Journal of Immunology Research

Pathogenesis of Bone Diseases: The Role of Immune System


Status
Published

1University of Bari, Bari, Italy

2University of Foggia, Foggia, Italy

3University of Torino, Torino, Italy

4Washington University School of Medicine, St. Louis, USA


Pathogenesis of Bone Diseases: The Role of Immune System

Description

Bone is a metabolically active tissue that undergoes continuous remodeling by two counteracting processes, bone formation and bone resorption. These events are strongly linked and tightly regulated to maintain skeletal homeostasis. The bone cells responsible for the dual processes include the bone-resorbing cells, for example, the osteoclasts, which are differentiated cells derived from hematopoietic cells of the monocyte-macrophage lineage, and bone forming cells, for example, the osteoblasts, which are of mesenchymal origin. Alteration of the differentiation/activity of osteoclasts as well as osteoblasts leads to bone diseases. Recently, the key role of immune cells in pathologies with bone involvement is emerging from the literature. Thus, a better understanding of the mechanisms governing the role of immune systems in bone diseases has potential for developing new therapeutic strategies for the treatment of disorders.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the prominent role of immune system in the alteration of bone remodeling, thus favoring bone disease development.

Potential topics include, but are not limited to:

  • The role of immune system in osteotropic solid and haematological malignancies
  • Immunoregulation of pathological bone loss in postmenopausal and secondary osteoporosis
  • Mechanisms of altered bone remodeling in autoimmune and inflammatory diseases
  • Immune system involvement in extra calcification sites (cardiac valves and vessels)
  • Latest therapeutic strategies targeting bone disease linked to immune cells

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 785845
  • - Editorial

Pathogenesis of Bone Diseases: The Role of Immune System

Giacomina Brunetti | Giorgio Mori | ... | Roberta Faccio
  • Special Issue
  • - Volume 2015
  • - Article ID 832127
  • - Review Article

Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

Dulshara Sachini Amarasekara | Jiyeon Yu | Jaerang Rho
  • Special Issue
  • - Volume 2015
  • - Article ID 214878
  • - Research Article

IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in Mice

Masako Yoshimatsu | Hideki Kitaura | ... | Noriaki Yoshida
  • Special Issue
  • - Volume 2015
  • - Article ID 192761
  • - Review Article

Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System

Juan Marcos Mucci | Paula Rozenfeld
  • Special Issue
  • - Volume 2015
  • - Article ID 376197
  • - Research Article

Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report

Maria Guadalupe Zavala-Cerna | Maria Cristina Moran-Moguel | ... | Jorge Ivan Gamez-Nava
  • Special Issue
  • - Volume 2015
  • - Article ID 901679
  • - Research Article

Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice

Fraser L. Collins | Jessica O. Williams | ... | Anwen S. Williams
  • Special Issue
  • - Volume 2015
  • - Article ID 281287
  • - Review Article

Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss

Tania N. Crotti | Anak A. S. S. K. Dharmapatni | ... | David R. Haynes
  • Special Issue
  • - Volume 2015
  • - Article ID 143526
  • - Review Article

The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors

Lucia D’Amico | Ilaria Roato
  • Special Issue
  • - Volume 2015
  • - Article ID 851945
  • - Review Article

Innate and Adaptive Immunity in Calcific Aortic Valve Disease

Patrick Mathieu | Rihab Bouchareb | Marie-Chloé Boulanger
  • Special Issue
  • - Volume 2015
  • - Article ID 192415
  • - Review Article

Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis

Adrese M. Kandahari | Xinlin Yang | ... | Quanjun Cui
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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