Journal of Immunology Research

Extracellular Matrix and Immune Niches in Human Disease


Publishing date
01 Mar 2021
Status
Closed
Submission deadline
16 Oct 2020

Lead Editor

1University of Muenster, Muenster, Germany

2Duke University, Durham, USA

3University of Duesseldorf, Duesseldorf, Germany

4The People's Liberation Army General Hospital, Beijing, China

This issue is now closed for submissions.
More articles will be published in the near future.

Extracellular Matrix and Immune Niches in Human Disease

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Extracellular matrix (ECM) has a broad impact on the basic function of immune cells: affecting cell survival, growth and differentiation, and determining cell shape and migration. As a potential organizer of immune cell compartments, ECM plays an important role in the establishment and maintenance of immune homeostasis under physiological conditions. ECM regulates cellular interaction in various pathological processes, including immune response and wound repair process. In addition, dynamic changes in the extracellular matrix network are also one of the basic features of the tumor microenvironment. ECM can exert effects directly on tumor cells, but can further regulate the development and metastasis of tumors by regulating blood supply and inflammatory cells in the tumor milieu. For example, ECM can remodel the tumor inflammatory microenvironment and tumor immunity by modulating the migration of immune cells.

Although we have a certain understanding of the basic structure of the extracellular matrix and its physiological and pathological functions, there are still many important questions to be answered in this field. The complexity of extracellular matrix is not only reflected in the distribution of extracellular matrix proteins throughout different tissues and organs, but also during different physiological and pathological processes. Fundamental studies are required to explore ECM-immune interactions that occur during tissue homeostasis and infectious diseases, inflammatory diseases as well as malignancy.

This special issue invites original research and review articles that further the understanding and clarify the related fundamental knowledge and underlying mechanism of the interplay between immune cells and their extracellular matrices, in order to explore new therapeutic strategies and improve clinical outcomes.

Potential topics include but are not limited to the following:

  • Immune cell-matrix interaction in the maintenance of tissue homeostasis
  • Immune cell-matrix interaction in tissue repair and regeneration
  • Immune cell-matrix interaction in infectious disease
  • Immune cell-matrix interaction in inflammatory diseases
  • Therapeutic strategies that modulate the extracellular matrix and immune niches in the tumor microenvironment
  • Current clinical perspectives of the ECM and immune niches

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 6645072
  • - Review Article

Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma

Khuloud Bajbouj | Rakhee K. Ramakrishnan | Qutayba Hamid
  • Special Issue
  • - Volume 2020
  • - Article ID 8873261
  • - Research Article

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury

Lanqing Meng | Qing Huang | ... | Lingzhang Meng
  • Special Issue
  • - Volume 2020
  • - Article ID 6644687
  • - Research Article

Effect of SIS3 on Extracellular Matrix Remodeling and Repair in a Lipopolysaccharide-Induced ARDS Rat Model

Qiong Liang | Qiqing Lin | ... | Liao Pinhu
  • Special Issue
  • - Volume 2020
  • - Article ID 8820355
  • - Research Article

The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response

Weiwei Fu | Hong Li | ... | Yujun Li
  • Special Issue
  • - Volume 2020
  • - Article ID 5097920
  • - Research Article

Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro

Feng Tian | Qiang Lu | ... | Tao Jiang
  • Special Issue
  • - Volume 2020
  • - Article ID 7263602
  • - Research Article

STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells

Xiangyu Wang | Fengmian Wang | ... | Rong Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 7671502
  • - Research Article

Effects of miR-373 Inhibition on Glioblastoma Growth by Reducing Limk1 In Vitro

Tao Peng | Tiejun Wang | ... | Lixiang Zhou
  • Special Issue
  • - Volume 2020
  • - Article ID 5746832
  • - Research Article

Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation

Jie Wang | Peiling Luo | ... | Lingzhang Meng
  • Special Issue
  • - Volume 2020
  • - Article ID 4904217
  • - Review Article

Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications

Haiming Wang | Zifan Liu | ... | Ran Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 8340329
  • - Research Article

MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Guang-Ang Tian | Chun-Jie Xu | ... | Ya-Hui Wang
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.600
Journal Citation Indicator0.600
Impact Factor4.818
 Submit

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.