Journal of Immunology Research

Extracellular Matrix and Immune Niches in Human Disease

Publishing date
01 Mar 2021
Submission deadline
16 Oct 2020

Lead Editor

1University of Muenster, Muenster, Germany

2Duke University, Durham, USA

3University of Duesseldorf, Duesseldorf, Germany

4The People's Liberation Army General Hospital, Beijing, China

Extracellular Matrix and Immune Niches in Human Disease

Call for papers

This Issue is now open for submissions.

Papers are published upon acceptance, regardless of the Special Issue publication date.

 Submit to this Special Issue


Extracellular matrix (ECM) has a broad impact on the basic function of immune cells: affecting cell survival, growth and differentiation, and determining cell shape and migration. As a potential organizer of immune cell compartments, ECM plays an important role in the establishment and maintenance of immune homeostasis under physiological conditions. ECM regulates cellular interaction in various pathological processes, including immune response and wound repair process. In addition, dynamic changes in the extracellular matrix network are also one of the basic features of the tumor microenvironment. ECM can exert effects directly on tumor cells, but can further regulate the development and metastasis of tumors by regulating blood supply and inflammatory cells in the tumor milieu. For example, ECM can remodel the tumor inflammatory microenvironment and tumor immunity by modulating the migration of immune cells.

Although we have a certain understanding of the basic structure of the extracellular matrix and its physiological and pathological functions, there are still many important questions to be answered in this field. The complexity of extracellular matrix is not only reflected in the distribution of extracellular matrix proteins throughout different tissues and organs, but also during different physiological and pathological processes. Fundamental studies are required to explore ECM-immune interactions that occur during tissue homeostasis and infectious diseases, inflammatory diseases as well as malignancy.

This special issue invites original research and review articles that further the understanding and clarify the related fundamental knowledge and underlying mechanism of the interplay between immune cells and their extracellular matrices, in order to explore new therapeutic strategies and improve clinical outcomes.

Potential topics include but are not limited to the following:

  • Immune cell-matrix interaction in the maintenance of tissue homeostasis
  • Immune cell-matrix interaction in tissue repair and regeneration
  • Immune cell-matrix interaction in infectious disease
  • Immune cell-matrix interaction in inflammatory diseases
  • Therapeutic strategies that modulate the extracellular matrix and immune niches in the tumor microenvironment
  • Current clinical perspectives of the ECM and immune niches


  • Special Issue
  • - Volume 2020
  • - Article ID 5746832
  • - Research Article

Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation

Jie Wang | Peiling Luo | ... | Lingzhang Meng
  • Special Issue
  • - Volume 2020
  • - Article ID 4904217
  • - Review Article

Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications

Haiming Wang | Zifan Liu | ... | Ran Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 8340329
  • - Research Article

MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Guang-Ang Tian | Chun-Jie Xu | ... | Ya-Hui Wang
  • Special Issue
  • - Volume 2020
  • - Article ID 8127281
  • - Research Article

Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis

Jingbin Zhou | Zhihong Zhao | ... | Yujie Liu
  • Special Issue
  • - Volume 2020
  • - Article ID 4036047
  • - Research Article

miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT

Pengyu Jing | Nianlin Xie | ... | Zhongping Gu
  • Special Issue
  • - Volume 2020
  • - Article ID 8130760
  • - Research Article

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Chunting Zhou | Wei Song | ... | Shuangqing Wang
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
Impact Factor3.327

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