Journal of Immunology Research

Type 1 Diabetes Immunological Tolerance and Immunotherapy


Publishing date
15 Jul 2011
Status
Published
Submission deadline
15 Jan 2011

1Laboratory of Immunoendocrinology, Institute of Pathology CHU-B23, University of Liege Center of Immunology (CIL), Sart Tilman, 4000 Liege, Belgium

2Department of Pathology and Immunology, Diabetes Institute, Rangos Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 USA

3Immunology Division, Department of Pediatric, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4


Type 1 Diabetes Immunological Tolerance and Immunotherapy

Description

Type 1 diabetes (T1D) is a chronic autoimmune disorder associated, in genetically susceptible individuals, with the generation and activation of autoreactive CD4+ and CD8+ T cells that infiltrate the pancreas and selectively destroy the insulin-producing β-cells in the islets. The impairment of T-cell tolerance in T1D has been reported at many levels including abnormal self-antigen presentation in the thymus and periphery, autoreactive T-cell resistance to apoptosis, unbalanced immunoregulatory T-cell function, and deregulation of Th1/Th2/Th17 axes. Despite the identification of type1 diabetes-associated autoantigens and their derived CD4+ and CD8+ T-cell epitopes, numerous antigen-specific immunoregulatory therapies have failed when evaluated for their utility in the prevention and treatment of T1D. In this special issue, we invite authors to submit original research and review articles highlighting the recent advances that have broadened our understanding of immunological tolerance and T1D vaccine strategies. Also, we welcome papers that seek to define immunoregulatory properties of T cells to provide new insights as to their potential for clinical use. We are interested in articles that explore salient aspects of T1D-associated tolerance and immunotherapy. Potential topics include, but are not limited to:

  • T1D-associated central and peripheral tolerance mechanisms
  • Elucidating the functional impairment in immunoregulatory T-cell function in T1D
  • New animal models to test and understand dysfunctional immunity in T1D
  • Identification of new beta islet-specific autoantigens
  • Development of antigen-based immunotherapeutic strategies to prevent or treat T1D
  • Clinical trials with novel antigen-specific immunoregulatory therapies

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 103738
  • - Editorial

Type 1 Diabetes Immunological Tolerance and Immunotherapy

Aziz Alami Chentoufi | Vincent Geenen | ... | Abdelaziz Amrani
  • Special Issue
  • - Volume 2011
  • - Article ID 513210
  • - Review Article

T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives

Roberto Mallone | Vedran Brezar | Christian Boitard
  • Special Issue
  • - Volume 2011
  • - Article ID 432016
  • - Review Article

Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same?

Brett Phillips | Massimo Trucco | Nick Giannoukakis
  • Special Issue
  • - Volume 2011
  • - Article ID 831704
  • - Research Article

Protection against Autoimmune Diabetes by Silkworm-Produced GFP-Tagged CTB-Insulin Fusion Protein

Qiaohong Meng | Wenfeng Wang | ... | Yaozhou Zhang
  • Special Issue
  • - Volume 2011
  • - Article ID 158735
  • - Research Article

Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

Thais A. Fornari | Paula B. Donate | ... | Geraldo A. Passos
  • Special Issue
  • - Volume 2011
  • - Article ID 630187
  • - Research Article

NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence

Jean N. Manirarora | Sarah A. Parnell | ... | Pascale Alard
  • Special Issue
  • - Volume 2011
  • - Article ID 349368
  • - Review Article

Thymic Self-Antigen Expression for the Design of a Negative/Tolerogenic Self-Vaccine against Type 1 Diabetes

Aziz Alami Chentoufi | Vincent Geenen
  • Special Issue
  • - Volume 2011
  • - Article ID 593863
  • - Review Article

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

Meghan M. Delmastro | Jon D. Piganelli
  • Special Issue
  • - Volume 2011
  • - Article ID 374859
  • - Research Article

IFN Regulatory Factors 4 and 8 Expression in the NOD Mouse

Gilles Besin | Simon Gaudreau | ... | Abdelaziz Amrani
  • Special Issue
  • - Volume 2011
  • - Article ID 286248
  • - Review Article

Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?

Slobodan Culina | Christian Boitard | Roberto Mallone
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision64 days
Acceptance to publication30 days
CiteScore3.330
Impact Factor3.404
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