Journal of Immunology Research

Multifaceted Roles of Neutrophils in Autoimmune Diseases


Publishing date
01 Feb 2019
Status
Published
Submission deadline
28 Sep 2018

Lead Editor

1Sichuan University, Chengdu, China

2University of Tennessee Health Science Center, Memphis, USA

3Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China


Multifaceted Roles of Neutrophils in Autoimmune Diseases

Description

Neutrophils, also known as polymorphonuclear leukocytes, are the most abundant type of granulocytes. As the most abundant type of white blood cells in most mammals, neutrophils are an essential barrier for host defense. Impaired development, maturation, function, and death of neutrophils lead to abnormal conditions in the immune system, which can initiate autoimmune disorders. The precise role of neutrophils in inflammatory autoimmune disease is poorly understood. Research advances in neutrophil biology and the role of neutrophils in systemic autoimmune disease will hopefully not only better define how neutrophils contribute to autoimmune disease but also identify potential, novel therapeutic targets for treatment of inflammation and autoimmune disease.

In recent years, neutrophils have emerged as players in the pathogenesis of various systemic autoimmune diseases and autoinflammatory syndromes. The objective of this special issue is thus to provide an opportunity for researchers and clinicians to publish results from their original basic, clinical, or translational studies on the multifaceted roles of neutrophils in the initiation, development, and pathogenesis of systemic autoimmune diseases. We also welcome reviews that focus on recent research in the field of neutrophils and autoimmune diseases.

Potential topics include but are not limited to the following:

  • Aberrant development and maturation of neutrophils in autoimmune diseases
  • Abnormal activation of neutrophils and inflammation
  • Ligand recognition by and intracellular signal transduction in neutrophils in inflammatory conditions
  • Mechanisms of neutrophil extracellular traps (NETs) formation in chronic inflammation
  • Impaired neutrophil death and autoinflammation
  • The mechanism and role of NETs formation in autoimmune disorders

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7896738
  • - Editorial

Multifaceted Roles of Neutrophils in Autoimmune Diseases

Yi Zhao | Tony N. Marion | Qian Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 2160192
  • - Research Article

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases

Caitlyn L. Holmes | Daeun Shim | ... | Miriam A. Shelef
  • Special Issue
  • - Volume 2019
  • - Article ID 8016254
  • - Review Article

Different Faces for Different Places: Heterogeneity of Neutrophil Phenotype and Function

Peiqing Yang | Yanhong Li | ... | Yi Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 3560180
  • - Review Article

Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity

Hang Yang | Tony N. Marion | ... | Martin Herrmann
  • Special Issue
  • - Volume 2018
  • - Article ID 9034695
  • - Research Article

Effect of CXCR2 Inhibition on Behavioral Outcomes and Pathology in Rat Model of Neuromyelitis Optica

Melina V. Jones | Michael Levy
  • Special Issue
  • - Volume 2018
  • - Article ID 8549329
  • - Review Article

Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

Weiqian Chen | Qin Wang | ... | Jin Lin
  • Special Issue
  • - Volume 2018
  • - Article ID 5349837
  • - Research Article

A Granulocyte-Specific Protein S100A12 as a Potential Prognostic Factor Affecting Aggressiveness of Therapy in Patients with Juvenile Idiopathic Arthritis

Krzysztof Orczyk | Elzbieta Smolewska
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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