Journal of Immunology Research

Intestinal Microbiota as Modulators of the Immune System


Publishing date
05 Dec 2014
Status
Published
Submission deadline
18 Jul 2014

1Antigen Presentation Research Group, Imperial College London 8 St Mark´s Hospital, Harrow, United Kingdom

2Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands

3Nutrition and Bromatology Group, Department of Analytical and Food Chemistry; Food Science and Technology Faculty, University of Vigo – Ourense Campus, Spain

4Departmento de Microbiologia y Bioquimica de Productos Lacteos, Instituto de Productos Lacteos de Asturias, Consejo Superior de Investigaciones Científicas, Villaviciosa, Spain


Intestinal Microbiota as Modulators of the Immune System

Description

The gastrointestinal immune system is exposed to a large amount of different products mainly innocuous [derived from “friendly” bacteria and/or food antigens] but sometimes also dangerous [such as infectious bacteria]. The commensal microbiota plays a central role modulating the outcome of immune responses in the gastrointestinal tract helping therefore to maintain immune homeostasis. Commensals also have the capacity to modulate several aspects of the host including not only the physiology and/or its nutritional status but also contributing to several diseases affecting the gut but also distant organs. Therefore, it is not surprising that the modulation of the gut microbiota has been revealed as a very promising area of research aiming at modulating the development and/or outcome of the immune system looking for an impact in the clinics.

Nonetheless, there are still many issues which remain obscure regarding the host/microbiota interaction. In this issue, we aim to gain depth into the current understanding of the microbiota as a modulator of the immune system in health and disease. Potential topics include, but are not limited to:

  • Animal models, cell lines, human studies and/or clinical trials
  • Microbiota composition in different locations (e.g. faecal Vs tissue samples) and/or changes with the age/gender of the host
  • Commensal microbiota and its effect on gastrointestinal diseases (inflammatory bowel diseases, coeliac disease, colorectal cancer, Helicobacter pylori…) and/or systemic diseases (multiple sclerosis, allergy, obesity, cardiovascular system/metabolism…)
  • Microbiota metabolism and effects on the host in the framework health/disease
  • Molecular mechanisms (target cells, receptors, signalling…) mediating the host/microbiota cross-talk
  • Effect of the host as selection factor for the microbiota (e.g. genetics, host-derived soluble factors…)
  • Modulating the commensal microbiota (e.g. prebiotics, probiotics, symbiotics, and/or faecal transplants) as a way to modulate the immune system
  • Protective effect of natural compounds on the gastrointestinal tract

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/immi/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 159094
  • - Editorial

Intestinal Microbiota as Modulators of the Immune System

Borja Sánchez | Miguel Gueimonde | ... | David Bernardo
  • Special Issue
  • - Volume 2015
  • - Article ID 361604
  • - Research Article

Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota

P. Carasi | S. M. Racedo | ... | M. C. Urdaci
  • Special Issue
  • - Volume 2015
  • - Article ID 527696
  • - Review Article

Toll-Like Receptor Mediated Modulation of T Cell Response by Commensal Intestinal Microbiota as a Trigger for Autoimmune Arthritis

Rebecca Rogier | Marije I. Koenders | Shahla Abdollahi-Roodsaz
  • Special Issue
  • - Volume 2015
  • - Article ID 614127
  • - Review Article

HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets

Kishanda Vyboh | Mohammad-Ali Jenabian | ... | Jean-Pierre Routy
  • Special Issue
  • - Volume 2015
  • - Article ID 931574
  • - Review Article

Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis

Carlos Magno da Costa Maranduba | Sandra Bertelli Ribeiro De Castro | ... | Fernando de Sá Silva
  • Special Issue
  • - Volume 2015
  • - Article ID 106743
  • - Research Article

Lactic Acid Bacteria Strains Exert Immunostimulatory Effect on H. pylori-Induced Dendritic Cells

Małgorzata Wiese | Andrzej Eljaszewicz | ... | Jacek Michałkiewicz
  • Special Issue
  • - Volume 2015
  • - Article ID 497056
  • - Review Article

CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

Katarina Radulovic | Jan Hendrik Niess
  • Special Issue
  • - Volume 2015
  • - Article ID 538171
  • - Research Article

Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, Two Strains Isolated from Human Milk, to Very Low and Extremely Low Birth Weight Preterm Infants: A Pilot Study

Laura Moles | Esperanza Escribano | ... | Irene Espinosa-Martos
  • Special Issue
  • - Volume 2015
  • - Article ID 321241
  • - Review Article

The Multifaceted Role of Commensal Microbiota in Homeostasis and Gastrointestinal Diseases

Marcelo José Barbosa Silva | Matheus Batista Heitor Carneiro | ... | Liliane Martins dos Santos
  • Special Issue
  • - Volume 2014
  • - Article ID 762514
  • - Research Article

Association of Helicobacter pylori and iNOS Production by Macrophages and Lymphocytes in the Gastric Mucosa in Chronic Gastritis

Lilia A. Cherdantseva | Oksana V. Potapova | ... | Vyacheslav A. Shkurupiy
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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