Journal of Immunology Research

Immunoregulation of Inflammation in Chronic Kidney Disease


Publishing date
22 Nov 2013
Status
Published
Submission deadline
05 Jul 2013

Lead Editor

1Department of Advanced Nephrology and Regenerative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

2Division of Nephrology, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA

3Department of Immunology, Kitasato University School of Medicine Sagamihara, Japan


Immunoregulation of Inflammation in Chronic Kidney Disease

Description

Chronic kidney disease (CKD) is one of the most commonly encountered diseases in clinical practice. It is estimated that one out of every ten adults in the world, that is, about 600 million people, suffer from CKD. There has been a marked increase in the number of patients showing progression to end-stage renal disease and requiring hemodialysis or other renal replacement therapy. There was a rapid, approximately 5-fold increase, in the number of persons requiring hemodialysis from 1990 until 2010. Also, CKD patients with or without diabetes are at a high risk of developing hypertension and other cardiovascular diseases, which can influence the life prognosis. CKDs are frequently treated with steroids and/or immunosuppressive agents. However, there are no established treatment regimens for CKDs induced by various underlying causes. Therefore, investigation of “immunoregulation of inflammation” is very important to develop novel treatment strategies for CKD. As one of the factors of the immune system, nuclear factor-kappa B (NF-kB) plays a central role in inflammation and regulates various key factors such as cytokine, chemokine, and cellular apoptosis. A thorough knowledge and understanding of immunoregulation of inflammation in CKD may lead to resolution of the mechanism of occurrence of CKD and provision of better care to patients.

We invite investigators to contribute original research articles as well as review articles that may serve as valuable resources to understand the development of treatment strategies for CKD. We are interested in articles exploring all aspects of the immune system related to the development of CKD in both humans and animal models. Potential topics include, but are not limited to:

  • Role of inflammation in CKDs derived from various causes, including diabetic nephropathy
  • Immunopathogenesis of CKD such as Lupus nephritis, anti-GBM glomerulonephritis, and ANCA-associated pauci-immune glomerulonephritis
  • Role of the immune system in local cell such as tubular, mesangial, or podocyte cell injury induced by various stimulations
  • Study of the mechanisms and pathways of transcriptional regulation of NF-kB in CKD
  • Role of apoptosis in inflammation associated with the development of CKD
  • Immune biomarkers for diagnosis, prediction of prognosis, and prediction of response to therapies in patients with CKD
  • Development of immunotherapeutic strategies for CKDs
  • Regenerative therapy based on immune responses in CKDs

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/author/submit/journals/cdi/ckd/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 897487
  • - Editorial

Immunoregulation of Inflammation in Chronic Kidney Disease

Osamu Takase | Kazuya Iwabuchi | Richard J. Quigg
  • Special Issue
  • - Volume 2013
  • - Article ID 836989
  • - Research Article

Contrasting Effects of Systemic Monocyte/Macrophage and CD4+ T Cell Depletion in a Reversible Ureteral Obstruction Mouse Model of Chronic Kidney Disease

Lee D. Chaves | Liby Mathew | ... | Tipu S. Puri
  • Special Issue
  • - Volume 2013
  • - Article ID 317682
  • - Review Article

Mediators of Inflammation and Their Effect on Resident Renal Cells: Implications in Lupus Nephritis

Susan Yung | Kwok Fan Cheung | ... | Tak Mao Chan
  • Special Issue
  • - Volume 2013
  • - Article ID 791262
  • - Research Article

LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice

Annica Hedberg | Premasany Kanapathippillai | ... | Kristin Andreassen Fenton
  • Special Issue
  • - Volume 2013
  • - Article ID 597920
  • - Review Article

Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease

Ana Cristina Simões e Silva | Flávia Cordeiro Valério | ... | Eduardo Araújo Oliveira
  • Special Issue
  • - Volume 2013
  • - Article ID 430239
  • - Review Article

MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis

Cristen B. Chafin | Christopher M. Reilly
  • Special Issue
  • - Volume 2013
  • - Article ID 984708
  • - Review Article

Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells

Hiroshi Tanaka | Tadaatsu Imaizumi
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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