Patients respond differently to medicines which can have side effects on certain individuals. Though the majority of adverse drug cutaneous reactions are mild and self-limiting, a minority of patients developed severe adverse drug reactions including anaphylaxis and severe systemic and bullous skin hypersensitivity.

The last few decades have brought many new insights and dramatically changed our view of drug hypersensitivity reactions. It is still unclear how small (and larger) drug molecules are able to interact with the immune system and elicit hypersensitivity, toxicity, autoimmunity. It is not easy to diagnose, as the resulting drug hypersensitivity is often puzzling, and the test procedures are not yet definitively established. As targeted immune therapies grow in complexity, understanding and controlling immune regulation in drug hypersensitivity may offer new design of therapeutics.

This special issue aims at creating recent advances in drug hypersensitivity research as well as new drug hypersensitivity management. Accepted papers will show new developments in these research areas. This issue accepts high quality articles containing original research results and it will let the readers of this journal know more new advances in drug hypersensitivity research and treatment.

Potential topics include but are not limited to the following:

• Epidemiology in drug hypersensitivity
• Genetics factors in drug hypersensitivity
• Immunology and immunotoxicology in drug hypersensitivity
• Cellular immunology in drug hypersensitivity
• Diagnostic tools in drug hypersensitivity
• Viruses and drug hypersensitivity
• IgE mediated anaphylaxis
• Advanced treatment in drug hypersensitivity