Journal of Immunology Research

New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases


Status
Published

1University of Georgia, Athens, USA

2Università Vita-Salute San Raffaele, Milan, Italy

3Technische Universität München, Munich, Germany

4Invisible Sentinel, Philadelphia, USA


New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases

Description

The role of the immune response as marker as well as therapeutic tool for the diagnosis and treatment of infectious diseases, is well ascertained and described; however, these concepts are continually evolving.

In the diagnostic field, the research of a specific humoral immune response has been used from a long time. In fact, the seropositivity is considered as an important key for the determination of an occurring infection. Recently, in addition to the classical investigation on the presence or absence of antibodies directed against specific antigens, the titer of specific antibodies, defined as index, is gaining importance as a prognostic marker for certain infectious diseases, for example, the introduction of the JCPyV-seropositivity, defined as the presence of specific anti-JCPyV antibodies, in the stratification of multiple sclerosis patients for the risk to develop progressive multifocal leukoencephalopathy.

The immune response is the key element to resolve an infection. For this reason, a therapeutic and a prophylactic strategy for infectious diseases is usually based on immune-based approaches. In particular, prophylactic strategies are principally focused on the stimulation of a specific immune response against the pathogen, that is, the active immunization. On the other hand, immunotherapeutic strategies are based on the concept of a passive immunization. In this case, immunoglobulins obtained from sera of immune individuals or by the cloning of recombinant antibodies (usually, antigen-specific monoclonal antibodies) are injected to protect a susceptible or infected host. In this regard, very recently, a cocktail of monoclonal antibodies is being considered as a possible treatment of Ebola virus infections.

Recently, in the context of a passive immunization, also the infusions of antigen-specific or engineered T cells, as an alternative treatment for infectious diseases, are being considered. As an example, chimeric antigen receptor- (CAR-) engineered T cells are increasingly gaining potential application also for the elimination of difficult-to-eradicate pathogens. In this regard, in the last few years, several CARs directed against different infectious agents, such as HIV, CMV, HBV, HCV, and A. fumigatus, have been described.

The purpose of this special issue is to publish high quality research paper and review articles that underline the use of immune-based approaches for the diagnosis and therapy of infectious diseases. Original, high quality contributions that are not yet published or that are not under review by other journals or peer-reviewed conferences are evaluated.

Potential topics include but are not limited to the following:

  • Immune-based diagnostic tools for infectious diseases
  • New immune-based approaches as prognostic markers for infectious diseases
  • Immunotherapeutic approaches against infectious diseases
  • Anti-infective monoclonal antibodies and their engineering
  • New prophylactic approaches against infectious diseases
  • Adoptive T cell therapy for infectious diseases
  • Engineered and redirected T cells for the treatment of infectious diseases

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3104719
  • - Editorial

New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases

Giuseppe A. Sautto | Roberta A. Diotti | ... | Kristen M. Kahle
  • Special Issue
  • - Volume 2017
  • - Article ID 8394593
  • - Research Article

Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status

Luca Formichella | Laura Romberg | ... | Markus Gerhard
  • Special Issue
  • - Volume 2017
  • - Article ID 5193572
  • - Review Article

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

E. S. Rovai | M. Holzhausen
  • Special Issue
  • - Volume 2017
  • - Article ID 3780697
  • - Review Article

Bacteriophages and Their Immunological Applications against Infectious Threats

Elena Criscuolo | Sara Spadini | ... | Roberto Burioni
  • Special Issue
  • - Volume 2017
  • - Article ID 5871043
  • - Research Article

Synthetic Peptides as Potential Antigens for Cutaneous Leishmaniosis Diagnosis

Juliana Seger Link | Silvana Maria Alban | ... | Vanete Thomaz Soccol
  • Special Issue
  • - Volume 2017
  • - Article ID 4828936
  • - Research Article

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Yuchen Xia | Xiaoming Cheng | ... | Ulrike Protzer
  • Special Issue
  • - Volume 2017
  • - Article ID 5874572
  • - Research Article

Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Mustela putorius furo)

Greg A. Kirchenbaum | Ted M. Ross
  • Special Issue
  • - Volume 2017
  • - Article ID 7931982
  • - Research Article

Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines

Chi-Won Choi | Edmond Changkyun Park | ... | Gun-Hwa Kim
  • Special Issue
  • - Volume 2017
  • - Article ID 7373196
  • - Research Article

Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport

Yanqun Xu | Iftekhar Mahmood | ... | Evi B. Struble
  • Special Issue
  • - Volume 2016
  • - Article ID 6760830
  • - Review Article

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction

Lenka Potocnakova | Mangesh Bhide | Lucia Borszekova Pulzova
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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