Journal of Immunology Research

Neutrophils: Their Role in Innate and Adaptive Immunity


Status
Published

1Universidad Nacional Autónoma de México, Mexico City, Mexico

2University of Geneva, Geneva, Switzerland

3University of California, San Francisco, USA


Neutrophils: Their Role in Innate and Adaptive Immunity

Description

Neutrophils are the most abundant leukocytes in the blood and constitute the first line of host defense against numerous infectious pathogens, including bacteria, fungi, protozoa, and large parasites. Neutrophils migrate to sites of inflammation and infection where they recognize and phagocytose invading microorganisms in order to kill them via different cytotoxic mechanisms. These include the production of reactive oxygen species, microbicidal substances stored in granules, and the release of their nuclear material in the form of neutrophil extracellular traps.

In recent years, it has become evident that neutrophils not only have a fundamental role in the acute phase of inflammation when they actively eliminate pathogens, but also are capable of modifying the overall immune response. Neutrophils can do this by exchanging information with macrophages, dendritic cells, and other cells of the adaptive immune system through either soluble mediators or direct cell-cell contact. In addition, neutrophils are being recognized as important players in cancer and atherosclerosis, as these cells can infiltrate tumors and the atherosclerotic plaque. Thus, neutrophils can have an influence on tumor progression and inflammation leading to various stages of atherosclerosis. It is then important to understand the role of neutrophils in these disorders in order to be able to regulate their function to alleviate these health problems.

The purpose of this special issue is to publish high-quality original research papers as well as review articles addressing recent issues on the role of neutrophils in shaping the immune response and the consequences this may have on important health issues such as resolution of inflammation, autoimmunity, and cancer.

Potential topics include, but are not limited to:

  • Phagocytosis
  • Neutrophil extracellular traps
  • Signal transduction pathways regulating neutrophil activation
  • Neutrophil homeostasis
  • Resolution of inflammation
  • Neutrophils in atherosclerosis
  • Neutrophils in cancer
  • Role of neutrophils against larger parasites such as Toxoplasma and Leishmania
  • Regulation of neutrophil function
  • Neutrophils as therapeutic targets

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 1469780
  • - Editorial

Neutrophils: Their Role in Innate and Adaptive Immunity

Carlos Rosales | Nicolas Demaurex | ... | Eileen Uribe-Querol
  • Special Issue
  • - Volume 2016
  • - Article ID 2349817
  • - Review Article

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

Dragana Odobasic | A. Richard Kitching | Stephen R. Holdsworth
  • Special Issue
  • - Volume 2016
  • - Article ID 2908034
  • - Research Article

Differential Use of Human Neutrophil Fcγ Receptors for Inducing Neutrophil Extracellular Trap Formation

Omar Rafael Alemán | Nancy Mora | ... | Carlos Rosales
  • Special Issue
  • - Volume 2016
  • - Article ID 8239258
  • - Review Article

Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance

Michelle Amantéa Sugimoto | Juliana Priscila Vago | ... | Lirlândia Pires Sousa
  • Special Issue
  • - Volume 2015
  • - Article ID 296149
  • - Research Article

Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux

Mélanie R. Tardif | Julie Andrea Chapeton-Montes | ... | Philippe A. Tessier
  • Special Issue
  • - Volume 2015
  • - Article ID 751014
  • - Research Article

Heparin Interaction with the Primed Polymorphonuclear Leukocyte CD11b Induces Apoptosis and Prevents Cell Activation

Meital Cohen-Mazor | Rafi Mazor | ... | Shifra Sela
  • Special Issue
  • - Volume 2015
  • - Article ID 983698
  • - Review Article

Neutrophils in Cancer: Two Sides of the Same Coin

Eileen Uribe-Querol | Carlos Rosales
  • Special Issue
  • - Volume 2015
  • - Article ID 187048
  • - Review Article

Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis

Haoshu Fang | Wei Jiang | ... | Uta Dahmen
  • Special Issue
  • - Volume 2015
  • - Article ID 794072
  • - Review Article

Neutrophil Leukocyte: Combustive Microbicidal Action and Chemiluminescence

Robert C. Allen
  • Special Issue
  • - Volume 2015
  • - Article ID 697193
  • - Review Article

Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks

Carlos F. M. Morris | Muhammad Tahir | ... | Wagner Fontes
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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