Journal of Immunology Research

Tumor Escape and Progression under Immune Pressure


Publishing date
27 Jul 2012
Status
Published
Submission deadline
27 Jan 2012

1Department of Microbiology & Immunology, Virginia Commonwealth University Massey Cancer Center, Richmond, VA 23298, USA

2Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Guggenheim 3-42D, Rochester, MN 55906, USA

3Departments of CITI and Hem/HCT, Beckman Research Institute, City of Hope National Medical Center, Beckman Center 3rd Floor, 1500 East Duarte Road, Duarte, CA 91010-3000, USA


Tumor Escape and Progression under Immune Pressure

Description

The fact that cancers develop and progress in immunocompetent hosts makes immunotherapy of cancer a daunting task. In the past decade, we have learned that interactions between tumor cells and cells of the immune system result in the induction of epigenetic changes in the tumor cells and selection of less immunogenic clones as well as alterations in the immune responses including an increased myeloid-derived suppressor cells (MDSCs) and/or Tregs. Knowledge and understanding of cross-talk between nascent transformed cells and cells of the immune system have led to the development of combinatorial immunotherapeutic strategies to overcome cancer.

We invite authors to submit original research as well as review articles that seek to define the interaction between nascent transformed cells and the host immune system. We are particularly interested in articles that explore cooperation of the innate and adaptive immune systems to overcome or to facilitate cancer progression. Potential topics include, but are not limited to:

  • Role of host immune system in the induction of epigenetic changes in the tumors
  • Interaction of cancer stem cells with cells of the immune system
  • Role of the innate immune system in determining the outcome of adaptive immune responses to cancer
  • New animal models in tumor immunology research
  • Role of infectious diseases in changing the cross-talk between tumor cells and the immune system
  • Homeostatic counterregulation in cancer immune therapy. This topic would include both T-cell intrinsic negative checkpoint molecules (CTLA-4, PD-1, etc.) and posttherapy T-regulatory cell expansion
  • Role of proteinases and inhibitors, made by immune cells and the tumor environment, as well as their catalytic and noncatalytic effects on tumor cell proliferation, antiapoptosis, invasion, and metastasis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:

Manuscript DueFriday, 27 January 2012
First Round of ReviewsFriday, 27 April 2012
Publication DateFriday, 27 July 2012

Lead Guest Editor

  • Masoud H. Manjili, Department of Microbiology & Immunology, Virginia Commonwealth University Massey Cancer Center, Richmond, VA 23298, USA

Guest Editors

  • Nejat Egilmez, Department of Microbiology and Immunology, University at Buffalo, 138 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
  • Keith L. Knutson, Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Guggenheim 3-42D, Rochester, MN 55906, USA
  • Senthamil R. Selvan, Department of Medical Oncology, Thomas Jefferson University, Curtis Building, 10th Floor, 1021 Walnut Street, Philadelphia, PA 19107, USA
  • Julie R. Ostberg, Departments of CITI and Hem/HCT, Beckman Research Institute, City of Hope National Medical Center, Beckman Center 3rd Floor, 1500 East Duarte Road, Duarte, CA 91010-3000, USA

Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 641079
  • - Editorial

Tumor Escape and Progression under Immune Pressure

Masoud H. Manjili | Nejat Egilmez | ... | Julie R. Ostberg
  • Special Issue
  • - Volume 2012
  • - Article ID 756353
  • - Review Article

Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications

Luis de la Cruz-Merino | Marylène Lejeune | ... | Tomás Álvaro
  • Special Issue
  • - Volume 2012
  • - Article ID 192719
  • - Review Article

Lessons from Cancer Immunoediting in Cutaneous Melanoma

Mariana Aris | María Marcela Barrio | José Mordoh
  • Special Issue
  • - Volume 2012
  • - Article ID 421702
  • - Review Article

Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications

Laure Farnault | Carole Sanchez | ... | Régis T. Costello
  • Special Issue
  • - Volume 2012
  • - Article ID 160724
  • - Review Article

Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

Martin R. Jadus | Josephine Natividad | ... | Maria G. Dacosta-Iyer
  • Special Issue
  • - Volume 2012
  • - Article ID 927240
  • - Review Article

New Roads Open Up for Implementing Immunotherapy in Mesothelioma

R. Cornelissen | M. E. Heuvers | ... | J. P. J. J. Hegmans
  • Special Issue
  • - Volume 2012
  • - Article ID 948098
  • - Review Article

Macrophages in Tumor Microenvironments and the Progression of Tumors

Ning-Bo Hao | Mu-Han Lü | ... | Shi-Ming Yang
  • Special Issue
  • - Volume 2012
  • - Article ID 818214
  • - Review Article

Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms

Sivan Sapoznik | Ohad Hammer | ... | Gal Markel
  • Special Issue
  • - Volume 2012
  • - Article ID 146463
  • - Research Article

Immune Responses to RHAMM in Patients with Acute Myeloid Leukemia after Chemotherapy and Allogeneic Stem Cell Transplantation

R. Casalegno-Garduño | C. Meier | ... | M. Schmitt
  • Special Issue
  • - Volume 2012
  • - Article ID 124187
  • - Review Article

Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape

Gang Zhou | Hyam Levitsky
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision62 days
Acceptance to publication33 days
CiteScore5.100
Impact Factor3.327
 Submit

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.