Journal of Immunology Research

Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics


Status
Published

Lead Editor

1Pennsylvania State University, Hershey, USA

2Boston University, Boston, USA

3Nanjing University, Nanjing, China

4University of Pittsburgh, Pittsburgh, USA


Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics

Description

Macrophages, as a key element in the innate immunity, play an important role in the first-line defense against the pathogens and modulating inflammatory responses. Circulating monocytes derived from bone marrow myeloid progenitors differentiate into tissue macrophages through a fine-regulated process. Macrophages are not homogenous and they are generally categorized into two broad but distinct subsets as either classically activated (M1) or alternatively activated (M2). In general, M1 macrophages promote inflammation while M2 macrophages help to resolve inflammation and promote tissue remodeling. However, sustained macrophage infiltration in face of injury eventually becomes pathological, resulting in irreversible tissue destruction and disease progression and deterioration. Thus, better understanding of the regulation of macrophage differentiation and polarization, as well as their roles in disease pathogenesis, will contribute to the development of selective and effective therapies.

We invite authors to contribute original research articles, as well as review articles, of both in vitro and in vivo studies using animal and human models to this special issue.

Potential topics include but are not limited to the following:

  • Mechanisms of macrophage differentiation
  • Regulation of macrophage polarity
  • Regulation of macrophage fate (apoptosis and survival)
  • Crosstalk between macrophages and other cells in innate immunity
  • Role of macrophages in cardiovascular diseases
  • Role of macrophages in pulmonary diseases
  • Role of macrophages in kidney diseases
  • Role of macrophages in infectious diseases
  • Role of macrophages in cancer
  • Role of macrophages in neurological diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7590350
  • - Editorial

Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics

Kebin Hu | Yang Jin | ... | Ling Lin
  • Special Issue
  • - Volume 2018
  • - Article ID 1838921
  • - Research Article

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

Yazmin M. Flores-Martinez | Manuel A. Fernandez-Parrilla | ... | Daniel Martinez-Fong
  • Special Issue
  • - Volume 2018
  • - Article ID 5160794
  • - Review Article

Lung Interstitial Macrophages: Past, Present, and Future

Joey Schyns | Fabrice Bureau | Thomas Marichal
  • Special Issue
  • - Volume 2018
  • - Article ID 5783639
  • - Research Article

The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-α Expression in Macrophages

Wei-Ren Shen | Keisuke Kimura | ... | Hideki Kitaura
  • Special Issue
  • - Volume 2018
  • - Article ID 6827237
  • - Review Article

Roles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage

Jinyao Shi | Zhouqiao Wu | ... | Jiafu Ji
  • Special Issue
  • - Volume 2018
  • - Article ID 2349045
  • - Review Article

Dysregulated Functions of Lung Macrophage Populations in COPD

Theodore S. Kapellos | Kevin Bassler | ... | Joachim L. Schultze
  • Special Issue
  • - Volume 2018
  • - Article ID 8695157
  • - Review Article

Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance

Ranferi Ocaña-Guzman | Luis Vázquez-Bolaños | Isabel Sada-Ovalle
  • Special Issue
  • - Volume 2018
  • - Article ID 5201759
  • - Review Article

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

Liqian Zhu | Clinton Jones | Gaiping Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 1436236
  • - Research Article

Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias

Masahiro Yamashita | Ryoko Saito | ... | Makoto Maemondo
  • Special Issue
  • - Volume 2018
  • - Article ID 8917804
  • - Review Article

Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

Luca Parisi | Elisabetta Gini | ... | Lorenzo Mortara
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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