Journal of Immunology Research

Dendritic Cells in Tolerance and Immunity against Pathogens


Status
Published

1University of São Paulo, São Paulo, Brazil

2Federal University of São Paulo, São Paulo, Brazil

3Emory University, Atlanta, USA

4Roche Innovation Center Zurich, Zurich, Switzerland


Dendritic Cells in Tolerance and Immunity against Pathogens

Description

Infectious diseases have always been a concern for human health. Survival depends heavily on an individual’s ability to control and eliminate a variety of pathogens. Generally, our innate immune system deals with the majority of invading organisms before they can even establish a successful infection. However, some pathogens are able to surpass these defenses and invade different tissues and organs. When this happens, our bodies resort to a second line of defense that is collectively known as adaptive immunity and comprises the activation of T and B cells. Adaptive immunity provides long-term and specific protection through antibodies and memory T cells.

Dendritic cells (DCs) are a highly specialized population of antigen-presenting cells that play a key role in the induction of adaptive immune responses against different pathogens and in the maintenance of peripheral tolerance. Since their discovery by Ralph Steinman in the 70s, much has been learned about their ontogeny, migration, and antigen presentation capacities in lymphoid and nonlymphoid organs. Advances in flow cytometry allowed the selection of surface markers that help distinguish different DC subpopulations. In addition, the identification of many receptors has added information on how these cells sense the environment and respond to different stimuli. The role of DCs in the induction of immune responses and/or peripheral tolerance has been studied using mouse models that lack the whole DC population or even specific subpopulations. In mice, much has been learned about how distinct DC subpopulations regulate immune responses against different pathogens or self-antigens. In recent years, knowledge about DC subpopulations in humans has also increased, and differences and similarities to murine DC subpopulations still need to be fully explored. DCs have been used as “natural adjuvants” in an attempt to induce immune responses especially against tumors. Novel vaccination strategies that efficiently engage DCs are needed to induce long lasting T- and B-cell responses.

Dissecting the different functions of DCs in such complex scenarios as immunity or tolerance is fundamental for our understanding of how our immune system deals with infections and maintains the steady state. Such knowledge could be used in the design of better vaccines and also in the treatment of autoimmune diseases.

Potential topics include, but are not limited to:

  • DC biology
  • DC development and precursors
  • Regulation of immune responses by DCs
  • DCs and induction of tolerance
  • Pattern recognition by DCs
  • DC intracellular signaling
  • DC as vaccines

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6438036
  • - Editorial

Dendritic Cells in Tolerance and Immunity against Pathogens

Silvia Beatriz Boscardin | Daniela Santoro Rosa | ... | Christine Trumpfheller
  • Special Issue
  • - Volume 2016
  • - Article ID 2926436
  • - Review Article

Dendritic Cells and Their Multiple Roles during Malaria Infection

Kelly N. S. Amorim | Daniele C. G. Chagas | ... | Silvia B. Boscardin
  • Special Issue
  • - Volume 2016
  • - Article ID 4753607
  • - Review Article

Sensitivity of Dendritic Cells to Microenvironment Signals

Juliana Maria Motta | Vivian Mary Rumjanek
  • Special Issue
  • - Volume 2016
  • - Article ID 5946807
  • - Review Article

Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies

Maja-Theresa Dieterlen | Katja John | ... | Markus J. Barten
  • Special Issue
  • - Volume 2016
  • - Article ID 6269157
  • - Review Article

Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells

Xiaofeng Liao | Alec M. Reihl | Xin M. Luo
  • Special Issue
  • - Volume 2016
  • - Article ID 9747480
  • - Research Article

Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis?

Thomas Bertran | Patrick Brachet | ... | Bertrand Evrard
  • Special Issue
  • - Volume 2016
  • - Article ID 5290604
  • - Research Article

Group B Streptococcus Induces a Robust IFN-γ Response by CD4+ T Cells in an In Vitro and In Vivo Model

Damian Clarke | Corinne Letendre | ... | Mariela Segura
  • Special Issue
  • - Volume 2016
  • - Article ID 1958650
  • - Review Article

Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice

Alex Steimle | Julia-Stefanie Frick
  • Special Issue
  • - Volume 2016
  • - Article ID 5134329
  • - Review Article

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity

Sandra Winning | Joachim Fandrey
  • Special Issue
  • - Volume 2016
  • - Article ID 3967436
  • - Review Article

Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease

Daniel Feijó | Rafael Tibúrcio | ... | Natalia Tavares
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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