Journal of Immunology Research

Immunobiology and Pharmacologic Manipulation of Dendritic and Regulatory Cells


Publishing date
21 Jun 2013
Status
Published
Submission deadline
01 Feb 2013

Lead Editor

1Hematology Department, Saint-Antoine Hospital and INSERM UMR S 938, Université Pierre et Marie Curie, Paris, France

2Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel

3Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany

4INSERM UMR1098, EFS Bourgogne Franche-Comté, Université de Franche-Comté, Besançon, France


Immunobiology and Pharmacologic Manipulation of Dendritic and Regulatory Cells

Description

Antigen presenting cells (APCs), especially dendritic cells (DCs), play a major role in the hierarchy of the induction of immune reactions. DCs are widely accepted as the most potent APCs capable of inducing protective adaptive immune responses in addition to tolerance to self-antigens. The role of DCs is currently being investigated in the context of many disease and therapeutic settings. In response to a variety of microbial and endogenous stimuli, resting DCs in peripheral tissues undergo a complex maturation process that might involve the regulation of genes that control distinct DC functions. The different functional properties of DCs are also linked to the existence of several subpopulations in humans and animals that differ in response to stimuli.

On the other hand, immune reactions can be controlled by the so-called regulatory T cells that can interact with APCs such as DCs. The most commonly known and explored regulatory T cells, namely, Tregs, are CD4+CD25highFoxP3highCD127low in humans. They have been studied in different autoimmune diseases but also in the transplant setting. The invariant NKT (iNKT) lymphocytes represent another immunoregulatory T-cell population whose functions are being progressively deciphered.

In all, DCs and regulatory lymphocytes are currently being considered as attractive targets towards manipulation of the immune system for therapeutic purposes. With this background, this special issue will be focussed on topics addressing the role, functions, and pathophysiology of DCs and regulatory cells and their interactions with other immune effectors. We are interested in papers that explore aspects of DC and regulatory cells immunobiology in humans and also in animal models. Potential topics include, but are not limited to:

  • Development and testing of novel and effective immunotherapeutic tools based on DCs and/or regulatory cells
  • Development of pharmacologic strategies to manipulate DCs and/or regulatory cells
  • Elucidating the role of DCs and/or regulatory cells in different physiological and pathological conditions
  • Identifying biomarkers/correlates of immunity in response to DC and/or regulatory cells vaccines
  • New cellular and animal models to test and understand the role of DCs and/or regulatory cells
  • The influence of immunomodulatory and immunosuppressive drugs on DC and/or regulatory cells properties

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/drc/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 186983
  • - Editorial

Immunobiology and Pharmacologic Manipulation of Dendritic and Regulatory Cells

Mohamad Mohty | Arnon Nagler | ... | Beatrice Gaugler
  • Special Issue
  • - Volume 2013
  • - Article ID 785317
  • - Review Article

New Insights into the Role of the Immune Microenvironment in Breast Carcinoma

Luis de la Cruz-Merino | Antonio Barco-Sánchez | ... | José Ibáñez Martínez
  • Special Issue
  • - Volume 2013
  • - Article ID 296031
  • - Research Article

Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

Corina Peña | David Gárate | ... | Juan C. Aguillón
  • Special Issue
  • - Volume 2013
  • - Article ID 390563
  • - Clinical Study

Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease

Paola Cordiali-Fei | Anna Mussi | ... | Fabrizio Ensoli
  • Special Issue
  • - Volume 2013
  • - Article ID 125643
  • - Research Article

Dextromethorphan Inhibits Activations and Functions in Dendritic Cells

Der-Yuan Chen | Pei-Shan Song | ... | Chi-Chen Lin
  • Special Issue
  • - Volume 2013
  • - Article ID 981468
  • - Clinical Study

Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation

Laura Adalid-Peralta | Asiel Arce-Sillas | ... | Edda Sciutto
  • Special Issue
  • - Volume 2013
  • - Article ID 806025
  • - Review Article

What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?

Rodrigo Nalio Ramos | Cristiano Jacob de Moraes | ... | José Alexandre M. Barbuto
  • Special Issue
  • - Volume 2013
  • - Article ID 701305
  • - Review Article

Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss

Selma Olsson Åkefeldt | Mohamad Bachar Ismail | ... | Christine Delprat
  • Special Issue
  • - Volume 2013
  • - Article ID 972865
  • - Review Article

Dendritic Cells: Cellular Mediators for Immunological Tolerance

Chun Yuen J. Chung | Dirk Ysebaert | ... | Nathalie Cools
  • Special Issue
  • - Volume 2013
  • - Article ID 210506
  • - Review Article

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance

Paulina Ruiz | Paula Maldonado | ... | Maria Rosa Bono
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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