Journal of Immunology Research

Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases


Publishing date
01 Dec 2011
Status
Published
Submission deadline
01 Jun 2011

Lead Editor

1Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway

2Department of Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary

3Department of Medicine, Johns Hopkins University, Baltimore, MD, USA


Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases

Description

Systemic autoimmune and rheumatic diseases (SAIRDs) encompass a range of disorders with a complex etiology and broad clinical manifestations. The intricate interplay of immunological processes leads to the development of these debilitating diseases. Physiologically, the immune system has multiple levels of negative feedback mechanisms that dampen immune responses and counteract establishment of chronic and destructive immunity. These immune-regulatory functions include a broad spectrum of cellular and molecular mechanisms. In autoimmune animal models and patients with SAIRD, various disorders of such regulatory mechanisms have been described. Knowledge and understanding of these immunomodulatory and pathogenic mechanisms can lead to the development of novel diagnostic strategies, and future therapies, providing better life expectancies to patients with SAIRD.

We invite investigators to contribute original research articles and review papers on the role of derailed regulatory mechanisms underlying SAIRD. The topic of these articles should encompass basic, molecular mechanisms of immune regulation in autoimmune processes, cellular and molecular immune-regulatory functions, which can aid as biomarkers for diagnostics, as well as potential targeting of the immune-regulatory machinery, as possible therapeutic interventions. The call especially invites articles describing 1) the pathogenic role of dendritic cells, regulatory T- and B-cells, and regulatory cytokines in SAIRD, 2) advances in molecular genetics and molecular diagnostics, 3) new insights into defective regulatory functions in SAIRD, and 4) potential treatment options on modulating immune-regulatory processes, such as anticytokine therapy, small molecules, siRNA, or stem cells. Potential topics include, but are not limited to:

  • Recent developments in SAIRD research, with special emphasis on immune regulation
  • Advances in genetics of regulatory functions
  • Latest technologies for evaluating immune-regulatory functions
  • The role of regulatory T- and B-cells in the pathogenesis
  • Dendritic cells with immune-regulatory functions
  • Cytokines and cytokine-networks controlling immune functions in the pathogenesis
  • Modern therapeutic regimes, targeting regulatory cells and cytokines
  • Stem cells and immune regulation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 957151
  • - Editorial

Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases

Britt Nakken | Philip Alex | ... | Peter Szodoray
  • Special Issue
  • - Volume 2012
  • - Article ID 715190
  • - Review Article

Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus

Shui-Lian Yu | Woon-Pang Kuan | ... | Lai-Shan Tam
  • Special Issue
  • - Volume 2012
  • - Article ID 187258
  • - Research Article

Expression of IL-17, IL-23 and Their Receptors in Minor Salivary Glands of Patients with Primary Sjögren's Syndrome

Diana Mieliauskaite | Irena Dumalakiene | ... | Zygmunt Mackiewicz
  • Special Issue
  • - Volume 2012
  • - Article ID 350209
  • - Research Article

Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis

Zhijun Jiao | Wenhong Wang | ... | Huaxi Xu
  • Special Issue
  • - Volume 2012
  • - Article ID 970789
  • - Review Article

Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis

Shyi-Jou Chen | Yen-Ling Wang | ... | Huey-Kang Sytwu
  • Special Issue
  • - Volume 2012
  • - Article ID 941346
  • - Review Article

Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases

Yuya Takakubo | Yrjö T. Konttinen
  • Special Issue
  • - Volume 2012
  • - Article ID 295081
  • - Research Article

Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis

Yan Shi | Siamak Sandoghchian Shotorbani | ... | Huaxi Xu
  • Special Issue
  • - Volume 2012
  • - Article ID 490148
  • - Review Article

CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Nada Alaaeddine | Ghada S. Hassan | ... | Walid Mourad
  • Special Issue
  • - Volume 2012
  • - Article ID 369432
  • - Review Article

The Tumor Necrosis Factor Superfamily of Cytokines in the Inflammatory Myopathies: Potential Targets for Therapy

Boel De Paepe | Kim K. Creus | Jan L. De Bleecker
  • Special Issue
  • - Volume 2012
  • - Article ID 618608
  • - Research Article

Polymerized-Type I Collagen Induces Upregulation of Foxp3-Expressing CD4 Regulatory T Cells and Downregulation of IL-17-Producing CD4 T Cells (Th17) Cells in Collagen-Induced Arthritis

Janette Furuzawa-Carballeda | Perla Macip-Rodríguez | ... | Luis Llorente
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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