Journal of Immunology Research

Peptide-Based Immunotherapeutics and Vaccines 2015


Status
Published

Lead Editor

1Department of Immunology, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain

2Medicines Research Unit, Aston University, Birmingham B4 7ET, UK

3ATR, LLC, Worcester, MA 01606, USA

4Department of Mycobacteriology, National Institute of Infectious Diseases, Higashimurayama, Tokyo 189-0002, Japan


Peptide-Based Immunotherapeutics and Vaccines 2015

Description

An improved understanding of antigen presentation and recognition has enabled the development of new types of vaccines and immunotherapies based on synthetic peptides encompassing B- and T- cell epitopes. The design of such vaccines takes advantage of emergent computational and experimental technologies that facilitate the identification of epitopes within protein antigens.

Peptide-based vaccines offer several advantages over traditional vaccines. Chiefly, they allow the immune response to focus solely on relevant epitopes, avoiding those that lead to nonprotective responses, immune evasion, or unwanted side effects, such as autoimmunity. However, the development of effective peptide-based vaccines requires overcoming significant difficulties, including identifying optimal delivery routes, overcoming the low immunogenicity of peptides, combining different type of epitopes to engage the humoral and cellular arms of the adaptive immune response, and compensating for the poor population coverage of individual T-cell epitopes due to MHC restriction. Moreover, certain antigenic epitopes, specifically B-cell epitopes, are conformational and need to be mimicked by linear sequences or placed onto suitable spatial frameworks.

We invite authors to submit original research and review articles addressing any of these issues in the development of peptide-based vaccines against infectious diseases, cancer, allergy, and autoimmune diseases. Potential topics include, but are not limited to:

Potential topics include, but are not limited to:

  • New advances in epitope prediction and large-scale epitope discovery
  • Current progress in characterizing peptide repertoires presented by tumor and antigen presenting cells
  • New approaches for increasing peptide immunogenicity and optimizing the delivery of peptide-based vaccines
  • Development of peptide-based vaccines for the treatment of infectious diseases
  • Development of prophylactic and therapeutic peptide-based vaccines against cancer
  • Peptide-based immunotherapy for allergic and autoimmune diseases

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 349049
  • - Editorial

Peptide-Based Immunotherapeutics and Vaccines 2015

Pedro Reche | Darren R. Flower | ... | Yoshihiko Hoshino
  • Special Issue
  • - Volume 2015
  • - Article ID 762426
  • - Research Article

Comparative Immunogenicity in Rabbits of the Polypeptides Encoded by the 5′ Terminus of Hepatitis C Virus RNA

Irina Sominskaya | Juris Jansons | ... | Maria Isaguliants
  • Special Issue
  • - Volume 2015
  • - Article ID 738020
  • - Research Article

EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses

Magdalena Molero-Abraham | John-Paul Glutting | ... | Pedro A. Reche
  • Special Issue
  • - Volume 2015
  • - Article ID 763461
  • - Research Article

Automatic Generation of Validated Specific Epitope Sets

Sebastian Carrasco Pro | John Sidney | ... | Alessandro Sette
  • Special Issue
  • - Volume 2015
  • - Article ID 761820
  • - Review Article

Peptide-Based Treatment: A Promising Cancer Therapy

Yu-Feng Xiao | Meng-Meng Jie | ... | Shi-Ming Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 541282
  • - Research Article

Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination

Darja Kanduc | Candida Fasano | ... | Lorenzo Polimeno
  • Special Issue
  • - Volume 2015
  • - Article ID 527395
  • - Research Article

Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Mamiko Niki | Maho Suzukawa | ... | Yoshihiko Hoshino
  • Special Issue
  • - Volume 2015
  • - Article ID 473909
  • - Clinical Study

Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advanced Hepatocellular Carcinoma Patients

Shigeru Yutani | Kazuomi Ueshima | ... | Masanori Noguchi
  • Special Issue
  • - Volume 2015
  • - Article ID 723946
  • - Research Article

Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity

Ali N. Kamali | Patricia Marín-García | ... | José M. Bautista
  • Special Issue
  • - Volume 2015
  • - Article ID 786501
  • - Research Article

The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs

Akira Yano | Kaori Ito | ... | Mitsuhiro Makino
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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