Journal of Immunology Research

Immunotherapy of Liver Diseases


Publishing date
01 Nov 2018
Status
Published
Submission deadline
29 Jun 2018

Lead Editor

1National Institutes of Health, Bethesda, USA

2Beijing 302 Hospital, Beijing, China

3Shanghai Jiao Tong University, Shanghai, China

4Baylor College of Medicine, Houston, USA


Immunotherapy of Liver Diseases

Description

The liver is recognized as an immunological organ playing critical roles in fighting invading pathogens. It hosts hepatocytes and nonparenchymal cells. The nonparenchymal cells include large populations of immune cells such as Kupffer cells, natural killer (NK) cells, NKT cells, and other lymphocytes which have complex interactions with each other and with the hepatocytes, making the liver an important organ bridging innate immunity and adaptive immunity.

The dysregulation of immune cells in the liver is involved in almost all types of liver diseases, both acute and chronic. The innate immune response is an instant response to acute injury or infection involving mainly Kupffer cells, neutrophils, and NK cells. A longer adaptation process to injury and healing involves other cell types such as hepatocytes, hepatic stellate cells, and endothelial cells in addition to immune cells. Currently, effective treatment for inflammatory liver diseases remains limited. An improved understanding of the inflammatory processes responsible for the progression of liver diseases will be very helpful for developing novel and effective strategies for inflammatory liver disease treatment.

This special issue aims to discuss core immunological mechanisms underlying acute and chronic liver diseases and how to control the inflammatory response in the liver. This special issue will cover topics from basic science to translational and clinical studies. We would like to invite investigators to contribute original research articles as well as review articles to the special issue.

Potential topics include but are not limited to the following:

  • Targeting immune cells in the therapy for liver diseases
  • The interaction between immune cells and other cells in the development of liver diseases
  • The roles of immune cells in liver injury and repair
  • Immune regulation in pathogenesis of liver diseases
  • The dysregulation of immune cells in the development of liver cancer

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 9343505
  • - Editorial

Immunotherapy of Liver Diseases

Dechun Feng | YinYing Lu | ... | Feng Li
  • Special Issue
  • - Volume 2019
  • - Article ID 1538439
  • - Research Article

Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure

Geng-lin Zhang | Qi-yi Zhao | ... | Zhi-liang Gao
  • Special Issue
  • - Volume 2019
  • - Article ID 8325102
  • - Research Article

Immunoregulatory Effect of Koumine on Nonalcoholic Fatty Liver Disease Rats

Rongcai Yue | Guilin Jin | ... | Changxi Yu
  • Special Issue
  • - Volume 2019
  • - Article ID 7657294
  • - Research Article

Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

Jinbo Guo | Yuxin Luo | ... | Xiaolan Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 8983903
  • - Research Article

Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients

Long-Shan Ji | Qiu-Tian Gao | ... | Man Li
  • Special Issue
  • - Volume 2019
  • - Article ID 3954890
  • - Review Article

The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD

Minjuan Ma | Rui Duan | ... | Li Guo
  • Special Issue
  • - Volume 2018
  • - Article ID 9807139
  • - Research Article

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice

Meng Li | Min Xu | ... | Qiang Xia
  • Special Issue
  • - Volume 2018
  • - Article ID 8363265
  • - Research Article

Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines

Wei-Yi Lei | Shih-Chieh Hsiung | ... | Shuen-Kuei Liao
  • Special Issue
  • - Volume 2018
  • - Article ID 7283703
  • - Research Article

Mesenchymal Stem Cells Ameliorate Hepatic Ischemia/Reperfusion Injury via Inhibition of Neutrophil Recruitment

Shihui Li | Xu Zheng | ... | Yang Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 1509851
  • - Research Article

RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis

Zhenzhen Zhang | Guomin Xie | ... | Yan Wang
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision61 days
Acceptance to publication33 days
CiteScore5.100
Impact Factor3.327
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