Journal of Immunology Research

Impact of Metabolism on Immune Responses


Status
Published

Lead Editor

1Brigham and Women’s Hospital, Boston, USA

2University of Zurich, Zurich, Switzerland

3University of Valladolid, Valladolid, Spain


Impact of Metabolism on Immune Responses

Description

CD4+ T helper (Th) cells play a central role in regulating the adaptive immune response. Thus, a better understanding of the mechanisms that control T cell function and differentiation is essential for the development of novel therapeutic approaches to modulate immune function and prevent autoimmune and inflammatory diseases. To date, several CD4+ T helper cell subsets have been described (Th1, Th2, Th17, and Treg), each with a specific set of functions and characteristics. It is well established that the balance between these T cell subsets is critical in providing an adequate, but not overly zealous, immune response.

Increasing evidence suggests that T cell metabolism plays a cardinal feature in both T cell activation and T cell differentiation. Although T cells have been mainly characterized by their cytokine environment and respective master transcription factors, it has also been considered, for example, that specific programs and metabolites involved in energy metabolism are able to be potent regulators governing CD4+ T cell fate.

The goal of this special issue is to publish high-quality review articles as well as original research articles addressing the impact of metabolism on immune responses. A particular interest of this series will be given to articles related to innate and adaptive immune cells.

Potential topics include but are not limited to the following:

  • Roles of oxidative phosphorolysis and aerobic glycolysis in regulating innate and adaptive immune cells
  • Interplay of autophagy and energy metabolism
  • Changes in leukocyte energy metabolism with aging
  • The role of cofactors of energy metabolism (i.e., ATP, NAD+, and others) in regulating adaptive and innate immune responses
  • Impact of the microbiome and its metabolites on differentiation and activation of innate and adaptive immune cells
  • Altered metabolism in diseases and inflammation

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5069316
  • - Editorial

Impact of Metabolism on Immune Responses

Abdallah Elkhal | Hector Rodriguez Cetina Biefer | Miguel A. de la Fuente
  • Special Issue
  • - Volume 2018
  • - Article ID 1943497
  • - Review Article

Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

Yuze Yuan | Nan Ran | ... | Fang Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 1601079
  • - Research Article

Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1/Sle2/Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen

Michael H. Lee | Marita Chakhtoura | ... | Stefania Gallucci
  • Special Issue
  • - Volume 2018
  • - Article ID 1319272
  • - Research Article

Intermittent High Glucose Exacerbates A-FABP Activation and Inflammatory Response through TLR4-JNK Signaling in THP-1 Cells

Hui Li | Han-Ying Luo | ... | Ru-Ping Dai
  • Special Issue
  • - Volume 2018
  • - Article ID 2737040
  • - Research Article

High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes In Vitro

Johanna L. Grün | Aaron N. Manjarrez-Reyna | ... | Galileo Escobedo
  • Special Issue
  • - Volume 2018
  • - Article ID 8605471
  • - Review Article

Regulation of Immune Cell Functions by Metabolic Reprogramming

Jaehong Kim
  • Special Issue
  • - Volume 2018
  • - Article ID 3696914
  • - Review Article

How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases

Wenyi Zhou | Mingyi Zhao
  • Special Issue
  • - Volume 2018
  • - Article ID 2835761
  • - Review Article

Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response

Hong Zhong | Minjuan Ma | ... | Li Guo
  • Special Issue
  • - Volume 2017
  • - Article ID 5134760
  • - Review Article

Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

Amarjit Mishra
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision107 days
Acceptance to publication37 days
CiteScore3.330
Impact Factor3.404
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